Electron Spin Resonance Spectra on the Bloods in Diseased Conditions

Abstract

Bloods from normal volunteers and patients of various diseases were examined using the electron spin resonance technique at-196°C in a liquid nitrogen. Three major signals were detected ; g=4.2 for Fe (IQ) in transferrin, g=2.05 for Cu (II) in ceruloplasmin and g=2.00 for free radical. Electron spin resonance spectroscopy was found to be a good tool for monitoring the variation of blood metal elements and free radical in various disorders and for analysing the metabolic disturbance of oxidation-reduction system in the body. In vitamin C-deficient guinea pigs, Fe (III) and free radical signals were lower than those of the normal while Cu (II) signal was much higher. Such an abnormal pattern was demonstrated from the bloods of patients suffered from influenza. A possible value of vitamin C on these patients was discussed.

Estimation of the Malignancy of Pleural Effusions by Electron Spin Resonance

“…Then the true-positive rate and the falsepositive rate at the cutoff value of 3.70 were 1.00 and cancer, it has been reported that the intensity ratio, Cu 2/ /Fe 3/ , was high in most cases (9). In our pleural effusions, however, the Cu 2/ /Fe 3/ ratio was significantly lower in the cancer group than in the noncancer 0.17, respectively.…”

“…plasma, and serum are iron transferrin with a signal This value was estimated from a receiver-operating of g Å 4.2 and the copper ceruloplasmin with a signal of g Å 2.049 (2,(4)(5)(6)(7)(8)(9)(10)(11)(12)14). In the pleural effusions, we also observed the signals with g Å 4.2 and 2.049.…”

“…nance (ESR) 1 method on blood (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12). Some authors The peak-to-peak height was used as a measure of sighave reported that the patients with the malignant nal intensity, since the signal was confirmed to have diseases such as cancer and Hodgkin's disease had a constant line width and line shape in all the samples.…”

Ascorbate radical levels in human sera and rat plasma intoxicated with paraquat and diquat

“…Radical levels were decreased in human influenza patients and in vitamin C deficient guinea pigs (Kawasaki et al 1978). The levels decreased gradually with age in healthy human sera, and an appreciable correlation between radical levels and content of total ascorbic acid was observed in human sera (Sasaki et al 1983).…”

Histochemical and electron spin resonance study of serum metalloproteins in DAB hepatoma.

“…ESR studies by Foster et al (11) also demonstrated that the magnitude of the g=2.05 signal due to the copper ion bound to Cp increased significantly in sera of cancer patients to above that of normal individuals though no qualitative difference in ESR signals could be found between them. Recently, we reported that the plasma of advanced cancer patients showed relatively lower levels of Fe(III) signals as well as higher Cu(II) signals than those of the normal and, thus, the Cu(II)/Fe(III) signal ratio was higher in most cancer patients (18). Increased plasma Cp should be considered as a reflection of an overproduction in the liver.…”