2014
DOI: 10.1007/s13361-014-1047-0
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Electron Transfer Reduction of the Diazirine Ring in Gas-Phase Peptide Ions. On the Peculiar Loss of [NH4O] from Photoleucine

Abstract: Abstract. Electron transfer to gas-phase peptide ions with diazirine-containing amino acid residue photoleucine (L*) triggers diazirine ring reduction followed by cascades of residue-specific radical reactions. Upon electron transfer, substantial fractions of (GL*GGR +2H) +• cation-radicals undergo elimination of [NH O-labeled peptide ions and found to specifically involve the amide oxygen of the N-terminal residue. The structures, energies, and electronic states of the peptide radical species were elucidated … Show more

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Cited by 9 publications
(19 citation statements)
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“…The m/z 415 ion relative intensity amounted to 25% of combined relative intensities of z 1 -z 4 ions and the m/z 469 (loss of ammonia) fragment ion. The ETD spectrum of (GM*GGR + 2H) 2+ displayed only very minor peaks of fragment ions at m/z 454 (loss of N 2 H 4 ) and m/z 452 (loss of NH 4 O) that were both prominent in the ETD mass spectra of L*-containing peptide ions [7,8]. Hence, a minor structure change of replacing L* with M* had a major effect on ETD.…”
Section: Electron Transfer and Photodissociation Spectramentioning
confidence: 95%
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“…The m/z 415 ion relative intensity amounted to 25% of combined relative intensities of z 1 -z 4 ions and the m/z 469 (loss of ammonia) fragment ion. The ETD spectrum of (GM*GGR + 2H) 2+ displayed only very minor peaks of fragment ions at m/z 454 (loss of N 2 H 4 ) and m/z 452 (loss of NH 4 O) that were both prominent in the ETD mass spectra of L*-containing peptide ions [7,8]. Hence, a minor structure change of replacing L* with M* had a major effect on ETD.…”
Section: Electron Transfer and Photodissociation Spectramentioning
confidence: 95%
“…To accomplish photodissociation of trapped ions in the LIT, the LTQ-XL ETD mass spectrometer was modified as described previously [5,8]. The typical light intensity used in the photodissociation experiments was 15-20 mJ/pulse.…”
Section: Photodissociationmentioning
confidence: 99%
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