Electronic circuit system of high sensitivity mass detection for QCM-biosensor

Koyama, K.

doi:10.1109/freq.2004.1418572

Proceedings of the 2004 IEEE International Frequency Control Symposium and Exposition, 2004.

DOI: 10.1109/freq.2004.1418572

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Electronic circuit system of high sensitivity mass detection for QCM-biosensor

K. Koyama¹

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“…1 QCMs have also been used extensively as gas sensors. 2 The widespread use of these mass detectors can be attributed to a number of factors, including high sensitivity in the subnano-gram range, 3,4 relatively low-cost, ease of use, reliability, and broad applicability. QCMs are quite versatile, operable in both the gas and liquid phase, as well as under a range of pressure and temperature conditions.…”

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High Temperature Mass Detection Using a Carbon Nanotube Bilayer Modified Quartz Crystal Microbalance as a GC Detector

Benz

Patel

2015

Anal. Chem.

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A small, portable gas chromatograph (GC) was assembled for the trace detection of controlled substances using a novel quartz crystal microbalance sensor (QCM). The QCM crystal surface was modified with a variety of sorption materials to increase adsorption thereby amplifying mass detection. Single polymer thin film coatings increased the QCM response by 1–2 orders of magnitude, while operating at over 100 °C. Adding a layer of carbonaceous nanomaterial (graphene or carbon nanotubes) above such a film dramatically increased sensitivity by up to 3 orders of magnitude compared to uncoated crystals. Separation and detection of submicrogram quantities of controlled substances was carried out within minutes by employing a GC column and detector temperature ramp up to 220 °C. An additional 10-fold enhancement in sensitivity was achieved by mechanical abrasion of the sample swabs used in the sample introduction process. This study demonstrated a novel use of a polymer composite modified QCM as a chemical sensor at high temperatures.

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High Temperature Mass Detection Using a Carbon Nanotube Bilayer Modified Quartz Crystal Microbalance as a GC Detector

Benz

Patel

2015

Anal. Chem.

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Review about the Development of the Differential Expression QCM System

2017

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Electronic circuit system of high sensitivity mass detection for QCM-biosensor

Cited by 2 publications

References 4 publications

High Temperature Mass Detection Using a Carbon Nanotube Bilayer Modified Quartz Crystal Microbalance as a GC Detector

High Temperature Mass Detection Using a Carbon Nanotube Bilayer Modified Quartz Crystal Microbalance as a GC Detector

Review about the Development of the Differential Expression QCM System

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