Electronic control of drug release from gauze or cellulose acetate fibres for dermal applications

Baptista, Ana Catarina; Brito, Miguel Nogueira de; Marques, A.; Ferreira, I.

doi:10.1039/d1tb00249j

Cited by 12 publications

(5 citation statements)

References 21 publications

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“…The coating of hydrophobic sponge with a conducting polymer can convert its surface to hydrophilic one, and the contact angle could be varied (Stejskal et al 2008). The electroactivity of conducting polymers could be exploited in the control of adsorption processes by applying electrical potential (Baptista et al 2021;Xu et al 2021). In extended studies, polypyrrole can be replaced with polyaniline or polymers of ringsubstituted aniline derivatives, e.g.…”

Section: Discussionmentioning

confidence: 99%

Conducting polypyrrole-coated macroporous melamine sponges: a simple toy or an advanced material?

et al. 2021

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The present feature article offers a concise overview of recent research progress of the authors working in the design of macroporous conducting materials represented by polypyrrole-coated melamine sponges. The article highlights innovative results from the authors and suggests a perspective for future directions in the field of macroporous conducting polymer composites. The article also overviews this particular subject area and defines key challenges for this emerging field. The feasibility of diverse applications of polypyrrole/melamine sponges is demonstrated and includes deformation-sensitive materials, electromagnetic radiation shielding and electrically heated insulation materials. Cytotoxicity is addressed with respect to applications in biomedicine, and the adsorption of an organic dye serves as an example of the uses in environmental water-pollution treatment. A single-step deposition of polypyrrole during the oxidative polymerization of pyrrole provides the uniform coating of the sponge with an organic conducting phase. The conductivity of sponges was of the order of 10 -3 S cm -1 , increased with polypyrrole loading, and also by two orders of magnitude after the compression. Derived materials have also been prepared and tested. They are represented by polypyrrole-coated sponge converted by pyrolysis to a macroporous nitrogencontaining carbon, magnetic ferrosponge obtained by incorporation of magnetite, or the conventional globular polypyrrole coating replaced with polypyrrole nanotubes. Polypyrrole can also be simply decorated with silver nanoparticles. The macroporous conducting polypyrrole/melamine sponges and derived materials are considered to be of future scientific interest with broad application potential.

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Section: Discussionmentioning

confidence: 99%

Conducting polypyrrole-coated macroporous melamine sponges: a simple toy or an advanced material?

et al. 2021

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“…Although a similar behaviour was observed for all systems concerning the voltage values that lead to the highest drug retention, the voltage that maximised the IBU release ranged between +0.3 V, +0.5 V, and +0.8 V for the various systems. This inconsistency in values can be attributed to the possible bending of the systems during immersion in SBF, which can affect the distance between the electrodes [22].…”

Section: Drug Release Testsmentioning

confidence: 99%

“…The authors demonstrated that the relationship between the applied current, the content encapsulated in the fibrous layer of PPy, and the amount of drug released (dexamethasone, indomethacin, and aspirin) is linear. In 2021, Baptista et al [22] studied the electronically controlled release of ibuprofen (IBU) previously impregnated in gauze and CA membranes. They obtained a conductivity range of 1-10 mS/cm in gauze functionalised with PPy and CA fibres, providing a controlled drug release by electrical stimuli in a system composed of PPy/IBU/PPy membranes and a silver electrode.…”

Section: Introductionmentioning

confidence: 99%

Functionalisation of Electrospun Cellulose Acetate Membranes with PEDOT and PPy for Electronic Controlled Drug Release

et al. 2023

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Controlled drug release via electrical stimulation from drug-impregnated fibres was studied using electrospun cellulose acetate (CA) membranes and encapsulated ibuprofen (IBU). This research outlines the influence of polypyrrole (PPy) and poly(3,4-ethylenedioxythiophene) (PEDOT)-functionalised CA membranes and their suitability for dermal electronic-controlled drug release. Micro Raman analysis confirmed polymer functionalisation of CA membranes and drug incorporation. Scanning electron microscopy (SEM) images evidenced the presence of PPy and PEDOT coatings. The kinetic of drug release was analysed, and the passive and active release was compared. In the proposed systems, the drug release is controlled by very low electrical potentials. A potential of −0.3 V applied to membranes showed the ibuprofen retention, and a positive potential of +0.3 V, +0.5 V, or +0.8 V, depending on the conductive polymer and membrane configuration, enhanced the drug release. A small adhesive patch was constructed to validate this system for cutaneous application and verified an “ON/OFF” ibuprofen release pattern from membranes.

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“…Polypyrrole (Figure 1a) is of special interest for this type of applications because, in the contrast to polyaniline, it does not lose the conductivity under neutral and physiological conditions, and this applies especially to polypyrrole nanotubes 5–7 . This is important both for the environmental issues, such as water‐pollution treatment, 3 in biomedicine, 8 and with respect to drug delivery 9–11 . In addition to the dye‐adsorption ability of polypyrrole, its conductivity and electroactivity might become exploited in the control of adsorption by applying electric potential.…”

Section: Introductionmentioning

confidence: 99%

“…This makes conducting polymers a special potential class of electrically driven adsorbents. For example, the dye adsorption can be affected in this way 12 and the same principle was exploited in the controlled drug delivery 9,11,13,14 or in electrooxidative 15 and electrocatalytic 16 removal of pollutant dyes.…”

Section: Introductionmentioning

confidence: 99%

Adsorption of organic dyes on macroporous melamine sponge incorporating conducting polypyrrole nanotubes

Stejskal

Pekárek

Kolská

2022

J of Applied Polymer Sci

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The macropores of melamine sponge were coated with globular polypyrrole or polypyrrole nanotubes. The resulting materials have been tested for the adsorptive removal of organic dyes from aqueous medium. The nanotubes deposited on the sponge were able to remove Reactive Black 5 dye while the adsorption on analogous polypyrrole globules was marginal. For that reason, the macroporous open‐cell melamine sponge with embedded nanotubes was tested for the adsorption of five anionic and five cationic dyes. The anionic dyes were adsorbed efficiently in the contrast to cationic ones. This can be explained by the electrostatic interaction of anionic dyes with polypyrrole polycation. The fast‐starting adsorption occurred within a few minutes and was followed by a slower process extending for days. The nanotubes deposited on the sponge have always been more efficient adsorbents than free polypyrrole nanotubes or melamine sponge alone. Better organization of polymer chains in the polypyrrole nanotubes and especially those deposited on the melamine sponge is proposed to be responsible for this effect. Cationic dyes were adsorbed even by neat melamine sponge while the adsorption by polypyrrole was negligible. In this case, the indifferent role of polypyrrole can be assigned to the electrostatic repulsion of the dye.

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Electronic control of drug release from gauze or cellulose acetate fibres for dermal applications

Abstract: Electronic controlled drug release from fibres was studied using ibuprofen as a model drug, one of the most popular analgesics, to impregnate gauze and cellulose acetate (CA) membranes. Conductivity in...

Cited by 12 publications

References 21 publications

Conducting polypyrrole-coated macroporous melamine sponges: a simple toy or an advanced material?

Conducting polypyrrole-coated macroporous melamine sponges: a simple toy or an advanced material?

Functionalisation of Electrospun Cellulose Acetate Membranes with PEDOT and PPy for Electronic Controlled Drug Release

Adsorption of organic dyes on macroporous melamine sponge incorporating conducting polypyrrole nanotubes

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