Electronic neural interfaces

Zhang, Milin; Tang, Zijian; Liu, Xilin; Spiegel, Jan Van der

doi:10.1038/s41928-020-0390-3

Cited by 152 publications

(92 citation statements)

References 124 publications

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“…with desired properties (e.g., signal transduction, amplification, multiplexing, etc.) to achieve a complex, integrated biointerface system (Maiolo et al, 2019 ; Zhang et al, 2020 ). Organic semiconductors provide unique advantages of mechanical compliance, biodegradability, and stretchability.…”

Section: Electrode Materialsmentioning

confidence: 99%

A Review: Electrode and Packaging Materials for Neurophysiology Recording Implants

Yang

Gong

2021

Front. Bioeng. Biotechnol.

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To date, a wide variety of neural tissue implants have been developed for neurophysiology recording from living tissues. An ideal neural implant should minimize the damage to the tissue and perform reliably and accurately for long periods of time. Therefore, the materials utilized to fabricate the neural recording implants become a critical factor. The materials of these devices could be classified into two broad categories: electrode materials as well as packaging and substrate materials. In this review, inorganic (metals and semiconductors), organic (conducting polymers), and carbon-based (graphene and carbon nanostructures) electrode materials are reviewed individually in terms of various neural recording devices that are reported in recent years. Properties of these materials, including electrical properties, mechanical properties, stability, biodegradability/bioresorbability, biocompatibility, and optical properties, and their critical importance to neural recording quality and device capabilities, are discussed. For the packaging and substrate materials, different material properties are desired for the chronic implantation of devices in the complex environment of the body, such as biocompatibility and moisture and gas hermeticity. This review summarizes common solid and soft packaging materials used in a variety of neural interface electrode designs, as well as their packaging performances. Besides, several biopolymers typically applied over the electrode package to reinforce the mechanical rigidity of devices during insertion, or to reduce the immune response and inflammation at the device-tissue interfaces are highlighted. Finally, a benchmark analysis of the discussed materials and an outlook of the future research trends are concluded.

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Section: Electrode Materialsmentioning

confidence: 99%

A Review: Electrode and Packaging Materials for Neurophysiology Recording Implants

Yang

Gong

2021

Front. Bioeng. Biotechnol.

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“…Stimulation of nerve tissue is an essential tool in neurotherapeutics, neural prosthetics, and biomedical research. 1 Semiconductor and metal devices were already used as stimulation platforms in deep-brain stimulation to regulate brain activity and in neuroscientific research to recognize complex neural networks. However, the spatial resolution of the stimulating currents limits their efficacy and the electrical wiring of these devices also introduces difficulty in surgery.…”

Section: Introductionmentioning

confidence: 99%

Organic Photovoltaic Pseudocapacitors for Neurostimulation

Han

Srivastava

Yıldız

et al. 2020

ACS Appl. Mater. Interfaces

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Neural interfaces are the fundamental tools to understand the brain and cure many nervous-system diseases. For proper interfacing, seamless integration, efficient and safe digital-to-biological signal transduction, and long operational lifetime are required. Here, we devised a wireless optoelectronic pseudocapacitor converting the optical energy to safe capacitive currents by dissociating the photogenerated excitons in the photovoltaic unit and effectively routing the holes to the supercapacitor electrode and the pseudocapacitive electrode–electrolyte interfacial layer of PEDOT:PSS for reversible faradic reactions. The biointerface showed high peak capacitive currents of ∼3 mA·cm –2 with total charge injection of ∼1 μC·cm –2 at responsivity of 30 mA·W –1 , generating high photovoltages over 400 mV for the main eye photoreception colors of blue, green, and red. Moreover, modification of PEDOT:PSS controls the charging/discharging phases leading to rapid capacitive photoresponse of 50 μs and effective membrane depolarization at the single-cell level. The neural interface has a device lifetime of over 1.5 years in the aqueous environment and showed stability without significant performance decrease after sterilization steps. Our results demonstrate that adopting the pseudocapacitance phenomenon on organic photovoltaics paves an ultraefficient, safe, and robust way toward communicating with biological systems.

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“…[ 2,137 ] However, it is challenging to achieve both high‐quality signals from the targeted neurons and low‐current stimulation of tissues with minimized damages. [ 138,139 ] Although the electronics‐tissue interfaces would be formed in noninvasive ways through the skin, such as electroencephalogram, their signal cannot provide local information of specific brain regions of interest. Also, skin‐attached neural interfaces reflect large‐noise by merged signals.…”

Section: Applicationsmentioning

confidence: 99%

Liquid Metal‐Based Soft Electronics for Wearable Healthcare

Park

Lee

Jang

et al. 2021

Adv Healthcare Materials

156

100

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Wearable healthcare devices have garnered substantial interest for the realization of personal health management by monitoring the physiological parameters of individuals. Attaining the integrity between the devices and the biological interfaces is one of the greatest challenges to achieving high‐quality body information in dynamic conditions. Liquid metals, which exist in the liquid phase at room temperatures, are advanced intensively as conductors for deformable devices because of their excellent stretchability and self‐healing ability. The unique surface chemistry of liquid metals allows the development of various sensors and devices in wearable form. Also, the biocompatibility of liquid metals, which is verified through numerous biomedical applications, holds immense potential in uses on the surface and inside of a living body. Here, the recent progress of liquid metal‐based wearable electronic devices for healthcare with respect to the featured properties and the processing technologies is discussed. Representative examples of applications such as biosensors, neural interfaces, and a soft interconnection for devices are reviewed. The current challenges and prospects for further development are also discussed, and the future directions of advances in the latest research are explored.

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Electronic neural interfaces

Cited by 152 publications

References 124 publications

A Review: Electrode and Packaging Materials for Neurophysiology Recording Implants

A Review: Electrode and Packaging Materials for Neurophysiology Recording Implants

Organic Photovoltaic Pseudocapacitors for Neurostimulation

Liquid Metal‐Based Soft Electronics for Wearable Healthcare

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