2013
DOI: 10.1128/jcm.02838-12
|View full text |Cite
|
Sign up to set email alerts
|

Electronic Nose Technology for Detection of Invasive Pulmonary Aspergillosis in Prolonged Chemotherapy-Induced Neutropenia: a Proof-of-Principle Study

Abstract: Although the high mortality rate of pulmonary invasive aspergillosis (IA) in patients with prolonged chemotherapy-induced neutropenia (PCIN) can be reduced by timely diagnosis, a diagnostic test that reliably detects IA at an early stage is lacking. We hypothesized that an electronic nose (eNose) could fulfill this need. An eNose can discriminate various lung diseases through the analysis of exhaled volatile organic compounds (VOCs). An eNose is cheap and noninvasive and yields results within minutes. In a sin… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
1

Citation Types

2
58
0
1

Year Published

2014
2014
2021
2021

Publication Types

Select...
4
1
1

Relationship

0
6

Authors

Journals

citations
Cited by 87 publications
(61 citation statements)
references
References 38 publications
2
58
0
1
Order By: Relevance
“…Unfortunately, two already-published studies did not show that serial monitoring of galactomannan leads to an earlier diagnosis (15,16). Previously, we showed that patients with PCIN and IA have a distinct exhaled breath profile that can be discriminated by an electronic nose (eNose) (17). Very recently, this was confirmed by using gas chromatography-mass spectrometry (GC-MS), demonstrating exhaled metabolite signatures of Aspergillus fumigatus in vitro and IA in vivo (18).…”
mentioning
confidence: 63%
See 4 more Smart Citations
“…Unfortunately, two already-published studies did not show that serial monitoring of galactomannan leads to an earlier diagnosis (15,16). Previously, we showed that patients with PCIN and IA have a distinct exhaled breath profile that can be discriminated by an electronic nose (eNose) (17). Very recently, this was confirmed by using gas chromatography-mass spectrometry (GC-MS), demonstrating exhaled metabolite signatures of Aspergillus fumigatus in vitro and IA in vivo (18).…”
mentioning
confidence: 63%
“…Last, the current study strengthens the suggestion that eNose technology can detect such a distinct profile of metabolites produced by A. fumigatus in vivo by means of exhaled breath analysis. Our previous study already showed that invasive aspergillosis is associated with a distinctive breathprint, and as most subjects in the control group of that study had a pulmonary infection other than invasive aspergillosis, the distinct breathprint was unlikely to be caused by inflammation in general (17). eNose technology has been designed to capture and compare complex molecular mixtures (20).…”
Section: Discussionmentioning
confidence: 99%
See 3 more Smart Citations