Electronic nose versus quadrupole mass spectrometry for identifying viral hepatitis C patients

Mohamed, Ehab I.; Elghnam, Sameh M.; Bayoumi, Amani M.; Abdel-Mageed, Samir M.; Ghareeb, Doaa A.; Ross, Brian M.

doi:10.1111/jvh.13630

Journal of Viral Hepatitis

2021

DOI: 10.1111/jvh.13630

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Electronic nose versus quadrupole mass spectrometry for identifying viral hepatitis C patients

Ehab I. Mohamed

Sameh M. Elghnam

Amani M. Bayoumi

et al.

Abstract: Hepatitis C is a leading cause of liver disease and transplantation and is a significant burden on public health worldwide. This study aimed to apply the Electronic Nose (E-Nose) and quadrupole Mass Spectrometry (MS/MS) technologies for screening blood samples from hepatitis C patients and healthy controls. We analysed volatile organic compounds (VOCs) in the headspace over blood samples to identify those VOCs char-How to cite this article: Mohamed EI, El-Ghnam SM, Bayoumi AM, Abdel-Mageed SM, Ghareeb DA, Ross… Show more

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Cited by 5 publications

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Electronic nose versus VITEK 2 system for the rapid diagnosis of bloodstream infections

Mohamed,

Turkey,

Meshref

et al. 2023

Braz J Microbiol

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Infectious diseases that spread through the bloodstream, known as bloodstream infections (BSIs), are a major global health problem. Positive outcomes for patients with sepsis are typically the result of prompt treatment started after an early diagnosis of BSIs. In this study, we evaluated the capabilities of a portable electronic nose (E-Nose) to detect BSIs with two commonly isolated Gram-negative bacterial species, E. coli and K. pneumonia. One hundred and five blood samples were randomly collected for blood culture examinations using BACTEC and VITEK 2 system, and headspace analysis by an E-Nose from June to December 2021. Classification accuracy of E. coli, K. pneumonia, and negative controls was measured using principal component analysis, area under the receiver operating characteristic curve, sensitivity, and specificity analysis. After incubation for 24 h, cluster plots generated using principal component analysis demonstrated that E-Nose could accurately diagnose the presence of E. coli and K. pneumonia in BACTEC blood culture bottles with a sensitivity and specificity of 100% in just 120 s. The E-Nose method has been shown to be an immediate, precise, and cost-effective alternative to automated blood culture BACTEC and VITEK 2 systems for the fast detection of the causative bacterial pathogens of BSIs in clinical practice. Thus, patients with such Gram-negative bacteremia can have guided empirical antimicrobial therapy on the same day of BSIs diagnosis, which can be lifesaving.

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Electronic nose versus VITEK 2 system for the rapid diagnosis of bloodstream infections

Mohamed,

Turkey,

Meshref

et al. 2023

Braz J Microbiol

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Metabolomics of volatile organic compounds (VOCs) in infectious diseases

Sadaka,

Dalvand,

Faruqui

et al. 2024

TrAC Trends in Analytical Chemistry

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Optimization of Metal Oxide Nanosensors and Development of a Feature Extraction Algorithm to Analyze VOC Profiles in Exhaled Breath

et al. 2023

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Electronic nose versus quadrupole mass spectrometry for identifying viral hepatitis C patients

Cited by 5 publications

References 28 publications

Electronic nose versus VITEK 2 system for the rapid diagnosis of bloodstream infections

Electronic nose versus VITEK 2 system for the rapid diagnosis of bloodstream infections

Metabolomics of volatile organic compounds (VOCs) in infectious diseases

Optimization of Metal Oxide Nanosensors and Development of a Feature Extraction Algorithm to Analyze VOC Profiles in Exhaled Breath

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