“…I remember the first steps made in Freiburg (Germany) and Utrecht (The Netherlands) in the 1970s when the Dutch engineer Jan Somer provided an electronic sector scanning system with a stationary phasedarray transducer that allowed transtemporal insonation for a rather rough image of brain structures and arterial pulsations [1 ]. Clinical studies by Freund and coauthors [2], Kazner and Grumme [3], and Smith and colleagues [4] showed promising results as to the ability of the system to noninvasively detect space-occupying lesions, such as brain tumors, intracranial hemorrhages, and arterial venous malformation. However, without computerized data processing, the image quality was rather limited (Fig 1 ), as seems to be the case for today's transcranial color-coded duplex scanning, although in those days when A-mode ultrasound and angiography were the only methods to confirm a diagnosis like intracranial bleeding, they were of some value.…”