We report the Sr substitution effect in an antiferromagnetic insulator LaMnAsO. The Sr doping limit is x ∼ 0.10 under the synthesis conditions, as revealed by x-ray diffractions indicate. Upon Sr doping, the room-temperature resistivity drops by five orders of magnitude down to ∼0.01 Ω·cm, and the temperature dependence of resistivity shows essentially metallic behavior for x ≥0.08. Hall and Seebeck measurements confirm consistently that the insulator-to-metal transition is due to hole doping. Strikingly, the room-temperature Seebeck coefficient for the metallic samples is as high as ∼ 240µV/K, making the system as a possible candidate for thermoelectric applications.