“…Nonetheless, discoveries do not simply stop with a Nobel Prize; a deeper understanding of the quantum quirkiness of the electron, by moving beyond the deterministic constraints imposed by classical mechanics, has the potential to offer new ways of thinking in physiology (Bailey, ,b,d). Indeed, emerging evidence suggests that cerebral O 2 sensing is subject to redox regulation, relying specifically on the mitochondrial formation of the superoxide anion to trigger stabilization of hypoxia‐inducible factor‐1α (reviewed by Smith, Waypa, & Schumacker, ).…”