Electroosmosis-Driven Nanofluidic Diodes

Leong, Iat Wai; Tsutsui, Makusu; Murayama, Sanae; He, Yuhui; Taniguchi, Masateru

doi:10.1021/acs.jpcb.0c04677

Cited by 16 publications

(17 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Although a similar mechanism is used in Scanning electrochemical microscopy, 58,59 the application of a sensing strip to a Nanopore has not been shown for analytical purposes, although we note that placing buffers of different ionic strength and pH either side of the pore has been explored. 60,61 Paper Based Assays (PADs) are an area of increasing interest due to their low cost, viable mass production, ease of fabrication and modification and ease of disposability. 28,36,37 Previous work using ICR to detect metal ions has focused on binding recognition elements to the inner pore walls allowing the selective binding of specific analytes which in turn affect the ionic transport across the nanopore altering the I-V curve seen.…”

Section: Resultsmentioning

confidence: 99%

Multiuse Nanopore Platform with Disposable Paper Analytical Device for the Detection of Heavy Metal Ions

Heaton

Platt

2020

Ind. Eng. Chem. Res.

View full text Add to dashboard Cite

The pollution of heavy metal ions within the environmental is a global problem. The rapid and precise removal of these contaminants can be aided by identifying and quantifying the composition of the sample. It is therefore crucial to develop effective portable analytical techniques to determine the levels of heavy metal contamination.Paper-based analytical devices (PADs) offer a low-cost method making them an excellent platform for onsite environmental sensors. Here we demonstrate how a PAD can be integrated into a multi-use Nanopore platform. The PAD was functionalised with different recognition ligands, who's surface charge densities varied in the presence of an analyte. The surface of the PAD was placed in contact with a Nanopore which exhibited Ion Current Rectification (ICR). The extent of ICR, was dependent upon the PAD's surface charge, and the presence of the analyte of interest i.e. the ICR phenomena was exaggerated or diminished indicating the presence of the metal ion in solution.We demonstrate the potential of PAD-ICR using a PAD functionalised with a peptide aptamer specific for nickel ions. Allowing the detection of nickel(II) as low as 0.25 μM even in the presence of other metal ions. After any measurement, the Nanopore surface can be wiped clean, and reused. PAD-ICR can also be adapted as a multiplexed sensor. This is demonstrated using a PAD with three different DNA aptamers for simultaneous and specific detection of nickel, mercury, and lead ions.

show abstract

Section: Resultsmentioning

confidence: 99%

Multiuse Nanopore Platform with Disposable Paper Analytical Device for the Detection of Heavy Metal Ions

Heaton

Platt

2020

Ind. Eng. Chem. Res.

View full text Add to dashboard Cite

show abstract

“…Yossifon and coworkers developed microfluidic diodes [61] as well as poly-electrolyte-based microfluidic ionic rectifiers [62]. In larger open channels (e. g. in micropipettes) the flow of ions is accompanied by electroosmotic flow and both ion current and electroosmotic transport can be rectified [10,63,64,65]. A hybrid system can be introduced (to suppress electroosmotic flow) by combining a microhole with ionomer materials.…”

Section: Microscale Ionic Rectifiers: a Materials Approachmentioning

confidence: 99%

Microscale Ionic Diodes: An Overview

et al. 2021

View full text Add to dashboard Cite

Ionic rectifier membranes or devices generate uni-directional ion transport to convert an alternating current (AC) ion current input into stored energy or direct current (DC) in the form of ion/salt gradients. Electrochemical experiments 80 years ago were conducted on biological membrane rectifier systems, but today a plethora of artificial ionic rectifier types has been developed and electroanalytical tools are employed to explore mechanisms and performance. This overview focuses on microscale ionic rectifiers with a comparison to nano-and macroscale ionic rectifiers. The potential is surveyed for applications in electrochemical analysis, desalination, energy harvesting, electrochemical synthesis, and in selective ion extraction.

show abstract

“…The current-time response of the displacement process was curve-fitted to a theoretical expression to acquire the surface charge measurement. In addition, there are also numerous applications that involve EOF of several fluids, such as ionic transistor and diode [ 27 , 28 ], and transdermal drug delivery [ 29 ]. These examples [ 23 , 24 , 25 , 26 , 27 , 28 , 29 ] have demonstrated the importance of EOF on multiple fluid systems in practical applications.…”

Section: Introductionmentioning

confidence: 99%

“…In addition, there are also numerous applications that involve EOF of several fluids, such as ionic transistor and diode [ 27 , 28 ], and transdermal drug delivery [ 29 ]. These examples [ 23 , 24 , 25 , 26 , 27 , 28 , 29 ] have demonstrated the importance of EOF on multiple fluid systems in practical applications.…”

Section: Introductionmentioning

confidence: 99%

Electroosmotic Flow Hysteresis for Fluids with Dissimilar pH and Ionic Species

Lim

Lam

2021

Micromachines

View full text Add to dashboard Cite

Electroosmotic flow (EOF) involving displacement of multiple fluids is employed in micro-/nanofluidic applications. There are existing investigations on EOF hysteresis, i.e., flow direction-dependent behavior. However, none so far have studied the solution pair system of dissimilar ionic species with substantial pH difference. They exhibit complicated hysteretic phenomena. In this study, we investigate the EOF of sodium bicarbonate (NaHCO3, alkaline) and sodium chloride (NaCl, slightly acidic) solution pair via current monitoring technique. A developed slip velocity model with a modified wall condition is implemented with finite element simulations. Quantitative agreements between experimental and simulation results are obtained. Concentration evolutions of NaHCO3–NaCl follow the dissimilar anion species system. When NaCl displaces NaHCO3, EOF reduces due to the displacement of NaHCO3 with high pH (high absolute zeta potential). Consequently, NaCl is not fully displaced into the microchannel. When NaHCO3 displaces NaCl, NaHCO3 cannot displace into the microchannel as NaCl with low pH (low absolute zeta potential) produces slow EOF. These behaviors are independent of the applied electric field. However, complete displacement tends to be achieved by lowering the NaCl concentration, i.e., increasing its zeta potential. In contrast, the NaHCO3 concentration has little impact on the displacement process. These findings enhance the understanding of EOF involving solutions with dissimilar pH and ion species.

show abstract

Electroosmosis-Driven Nanofluidic Diodes

Cited by 16 publications

References 24 publications

Multiuse Nanopore Platform with Disposable Paper Analytical Device for the Detection of Heavy Metal Ions

Multiuse Nanopore Platform with Disposable Paper Analytical Device for the Detection of Heavy Metal Ions

Microscale Ionic Diodes: An Overview

Electroosmotic Flow Hysteresis for Fluids with Dissimilar pH and Ionic Species

Contact Info

Product

Resources

About