The present study presents a computational investigation into the thermal mixing along with entropy generation throughout the natural convection flow within an arbitrarily eccentric annulus. Salt water is filled inside the eccentric annulus, in which the outer and inner cylinders have Tc and Th constant temperatures. The Boussinesq approximation is used to develop the governing equations for the natural convection flow, which are then solved on a structured quadrilateral mesh using the OpenFOAM software package (FOAM-Extend 4.0). The computational simulations are performed for Rayleigh numbers (Ra=103–105), eccentricity (ϵ=0,0.4,0.8), angular positions (φ=0∘,45∘,90∘), and Prandtl number (Pr=10, salt water). The computational results are visualized in terms of streamlines, isotherms, and entropy generation caused by fluid friction and heat transfer. Additionally, a thorough examination of the variations in the average and local Nusselt numbers, circulation intensity with eccentricities, and angular positions is provided. The optimal state of heat transfer is shown to be influenced by the eccentricity, angular positions, uniform temperature sources, and Boussinesq state. Moreover, the rate of thermal mixing and the production of total entropy increase as Ra increases. It is found that, compared to a concentric annulus, an eccentric annulus has a higher rate of thermal mixing and entropy generation. The findings show which configurations and types of eccentric annulus are ideal and could be used in any thermal processing activity where a salt fluid (Pr=10) is involved.