Electroosmotic flow in a poly(dimethylsiloxane) channel does not depend on percent curing agent

Wheeler, Aaron R.; Trapp, Gabriele; Trapp, Oliver; Zare, Richard N.

doi:10.1002/elps.200305784

Cited by 34 publications

(30 citation statements)

References 21 publications

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“…Native PDMS with its negative surface charge supports EOF towards the cathode. 39 It can be seen that at both pH values investigated, APTES-modified PDMS microchannels supported EOF in the opposite direction to native PDMS. This is presumed to arise from the presence of net positive charge at the surface originating from the protonation of basic aminopropyl groups.…”

Section: B Reactivity Of Amine-functionalized Surface Of Aptes-modifmentioning

confidence: 91%

A rapid, inexpensive surface treatment for enhanced functionality of polydimethylsiloxane microfluidic channels

Beal¹,

Bubendorfer²,

Kemmitt³

et al. 2012

Biomicrofluidics

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A rapid, inexpensive method using alkoxysilanes has been developed to selectively coat the interior of polydimethylsiloxane (PDMS) microfluidic channels with an integral silicaceous layer. This method combines the rapid prototyping capabilities of PDMS with the desirable wetting and electroosmotic properties of glass. The procedure can be carried out on the open faces of PDMS blocks prior to enclosure of the channels, or by flowing the reagents through the preformed channels. Therefore, this methodology allows for high-throughput processing of entire microfluidic devices or selective modification of specific areas of a device. Modification of PDMS with tetraethoxysilane generated a stable surface layer, with enhanced wettability and a more stable electroosmotic flow rate than native PDMS. Modification of PDMS with 3-aminopropyltriethoxysilane generated a surface layer bearing amine functionalities allowing for further chemical derivatization of the PDMS surface.

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Section: B Reactivity Of Amine-functionalized Surface Of Aptes-modifmentioning

confidence: 91%

A rapid, inexpensive surface treatment for enhanced functionality of polydimethylsiloxane microfluidic channels

Beal¹,

Bubendorfer²,

Kemmitt³

et al. 2012

Biomicrofluidics

View full text Add to dashboard Cite

show abstract

“…However, their attenuated total reflection infrared (ATR-IR) spectroscopy experiments showed that oxygen plasma treated PDMS has large O-H stretches (which suggests the existence of silanol groups on the surface), while native PDMS does not; the absence of silanol spectroscopic features on native PDMS seems inconsistent with the hypothesis that silica filler impurities account for the surface charge. More recently, Wheeler et al [29] also found that m EO in PDMS does not depend on the relative amount of curing agent used, indicating that impurities, if important, seem insensitive to concentration.…”

Section: Impuritiesmentioning

confidence: 95%

Zeta potential and electroosmotic mobility in microfluidic devices fabricated from hydrophobic polymers: 1. The origins of charge

et al. 2008

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This paper combines new experimental data for electrokinetic characterization of hydrophobic polymers with a detailed discussion of the putative origins of charge at water-hydrophobe interfaces. Complexities in determining the origin of charge are discussed in the context of design and modeling challenges for electrokinetic actuation in hydrophobic microfluidic devices with aqueous working fluids. Measurements of interfacial charge are complicated by slip and interfacial water structuring phenomena (see Part 2, this issue). Despite these complexities, it is shown that (i) several hydrophobic materials, such as Teflon and Zeonor, have predictable electrokinetic properties and (ii) electrokinetic data for hydrophobic microfluidic systems is most consistent with the postulate that hydroxyl ion adsorption is the origin of charge.

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“…The inconsistency of the data was explained by the differences in the PDMS formulations used. PDMS microfluidic devices have been prepared using different ratios of the base component (which contains vinyl-terminated noncross-linked PDMS) to the curing agent (which contains silicon hydride groups) [33]. However, EOF in these PDMS devices was found to be constant for the PDMS formed with each ratio.…”

mentioning

confidence: 99%

Capillary zone electrophoresis of amino acids on a hybrid poly(dimethylsiloxane)-glass chip

et al. 2005

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Poly(dimethylsiloxane) (PDMS)-PDMS and hybrid PDMS-glass devices have been characterized and compared in terms of current-voltage linearity, contact angle, electroosmotic velocity, electroosmotic mobility, and electrokinetic potential in dependence on the surface treatment. The hybrid PDMS-glass microfluidic devices have further been tested as on-chip capillary electrophoresis systems for the separation of fluorescently labeled amino acids. It has been demonstrated that different methods of surface pretreatment of the PDMS-glass devices result in significantly different separation performance, with plate numbers varying from 650 to 57 000 in dependence on the surface state and the nature of the amino acids. Electrophoretic separations of amino acids have been achieved within tens of seconds with detection limits of less than 2 microM (approximately 2 x 10(-16) to 2.5 x 10(-16) mol quantities at injection volumes of 110-120 pL). The detected amounts of fluorescein isothiocyante (FITC)-amino acids are at least ten times lower, since the amino acid:FITC ratio is 10:1 mol. The results demonstrate the perspective of such hybrid PDMS-glass microfluidic systems and the methods to modify their surfaces for on-chip separation methods for biomolecules.

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Electroosmotic flow in a poly(dimethylsiloxane) channel does not depend on percent curing agent

Cited by 34 publications

References 21 publications

A rapid, inexpensive surface treatment for enhanced functionality of polydimethylsiloxane microfluidic channels

A rapid, inexpensive surface treatment for enhanced functionality of polydimethylsiloxane microfluidic channels

Zeta potential and electroosmotic mobility in microfluidic devices fabricated from hydrophobic polymers: 1. The origins of charge

Capillary zone electrophoresis of amino acids on a hybrid poly(dimethylsiloxane)-glass chip

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