Electroosmotic Flow Pump

Gao, Meng; Gui, Lin

doi:10.5772/64601

Cited by 6 publications

(14 citation statements)

References 60 publications

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“…Oh et al (2012) presented an interesting guide on design of microfluidic networks to ease fluid handling (Oh et al, 2012). Electroosmotic flow (EOF) offers an interesting alternative to pressure driven flow, where the flow front has a flat profile, being capable of generating high flowrates without moving parts (Gao and Gui, 2016). It has been widely applied in bioassays, drug delivery, fuel cells, sludge treatment and microelectronic chip cooling (Gao and Gui, 2016), (Lim et al, 2017).…”

Section: Available Unit Operations In Microfluidic Chipsmentioning

confidence: 99%

“…Electroosmotic flow (EOF) offers an interesting alternative to pressure driven flow, where the flow front has a flat profile, being capable of generating high flowrates without moving parts (Gao and Gui, 2016). It has been widely applied in bioassays, drug delivery, fuel cells, sludge treatment and microelectronic chip cooling (Gao and Gui, 2016), (Lim et al, 2017). Passive approaches to valves can also use capillary bursts, and stimuli-responsive hydrogels (Wang et al, 2005) (Boyd-Moss et al, 2016.…”

Section: Available Unit Operations In Microfluidic Chipsmentioning

confidence: 99%

“…A novel approach to passive control over mixing uses stimuliresponsive hydrogels (Prettyman and Eddington, 2011). Diverse active mixing strategies, such as acoustically-induced microstreams, dielectrophoretic micromixers, electrokinetic actuation (Gao and Gui, 2016), velocity pulsing and magnetohydrodynamic flow have also been thoroughly developed and applied (Lee et al, 2011). Mixing can also be performed in order to achieve gradients of certain components through dilution.…”

Section: Available Unit Operations In Microfluidic Chipsmentioning

confidence: 99%

“…A C C E P T E D M A N U S C R I P T (Sabourin et al, 2013);  Magnetically actuated stirrer-based micropump (Kimura et al, 2015);  Electroosmotic-based pump (Gao and Gui, 2016);  Screw-actuated valves (Zheng et al, 2009);  Braille display actuated valves (Gu et al, 2007);  Capillary-based valves (Madadi et al, 2015), (Boyd-Moss et al, 2016);  Hydrogel-based valves (Wang et al, 2005), (Ter Schiphorst et al, 2015), (Boyd-Moss et al, 2016);…”

Section: Accepted Manuscriptmentioning

confidence: 99%

“…Combination or blending of two or more substances or compounds  Passive mixing, such as channel topology (Liau et al, 2005), contact area increase (Lee et al, 2011), lamination (Gürsel et al, 2017), coiled flow inverter (Klutz et al, 2015) or stimuli-responsive hydrogels (Prettyman and Eddington, 2011);  Active mixing, such as acoustically-induced microstreams, dielectrophoretic micromixers, electrokinetic actuation (Gao and Gui, 2016), velocity pulsing and magneto-hydrodynamic flow have also been thoroughly developed and applied (Lee et al, 2011) Dilutions Definition of gradients of a target substance  Droplet-based (Niu et al, 2011);  Peristaltic mixing (Rho et al, 2016);…”

Section: Mixingmentioning

confidence: 99%

See 4 more Smart Citations

“Connecting worlds – a view on microfluidics for a wider application”

Fernandes

Gernaey

Krühne

2018

Biotechnology Advances

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From its birth, microfluidics has been referenced as a revolutionary technology and the solution to long standing technological and sociological issues, such as detection of dilute compounds and personalized healthcare. Microfluidics has for example been envisioned as: (1) being capable of miniaturizing industrial production plants, thereby increasing their automation and operational safety at low cost; (2) being able to identify rare diseases by running bioanalytics directly on the patient's skin; (3) allowing health diagnostics in point-of-care sites through cheap lab-on-a-chip devices. However, the current state of microfluidics, although technologically advanced, has so far failed to reach the originally promised widespread use. In this paper, some of the aspects are identified and discussed that have prevented microfluidics from reaching its full potential, especially in the chemical engineering and biotechnology fields, focusing mainly on the specialization on a single target of most microfluidic devices and offering a perspective on the alternate, multi-use, "plug and play" approach. Increasing the flexibility of microfluidic platforms, by increasing their compatibility with different substrates, reactions and operation conditions, and other microfluidic systems is indeed of surmount importance and current academic and industrial approaches to modular microfluidics are presented. Furthermore, two views on the commercialization of plug-and-play microfluidics systems, leading towards improved acceptance and more widespread use, are introduced. A brief review of the main materials and fabrication strategies used in these fields, is also presented. Finally, a step-wise guide towards the development of microfluidic systems is introduced with special focus on the integration of sensors in microfluidics. The proposed guidelines are then applied for the development of two different example platforms, and to three examples taken from literature. With this work, we aim to provide an interesting perspective on the field of microfluidics when applied to chemical engineering and biotechnology studies, as well as to contribute with potential solutions to some of its current challenges.

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Section: Available Unit Operations In Microfluidic Chipsmentioning

confidence: 99%

Section: Available Unit Operations In Microfluidic Chipsmentioning

confidence: 99%

Section: Available Unit Operations In Microfluidic Chipsmentioning

confidence: 99%

Section: Accepted Manuscriptmentioning

confidence: 99%

Section: Mixingmentioning

confidence: 99%

See 3 more Smart Citations

“Connecting worlds – a view on microfluidics for a wider application”

Fernandes

Gernaey

Krühne

2018

Biotechnology Advances

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Review: Electric field driven pumping in microfluidic device

et al. 2017

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Pumping of fluids with precise control is one of the key components in a microfluidic device. The electric field has been used as one of the most popular and efficient nonmechanical pumping mechanism to transport fluids in microchannels from the very early stage of microfluidic technology development. This review presents fundamental physics and theories of the different microscale phenomena that arise due to the application of an electric field in fluids, which can be applied for pumping of fluids in microdevices. Specific mechanisms considered in this report are electroosmosis, AC electroosmosis, AC electrothermal, induced charge electroosmosis, traveling wave dielectrophoresis, and liquid dielectrophoresis. Each phenomenon is discussed systematically with theoretical rigor and role of relevant key parameters are identified for pumping in microdevices. We specifically discussed the electric field driven body force term for each phenomenon using generalized Maxwell stress tensor as well as simplified effective dipole moment based method. Both experimental and theoretical works by several researchers are highlighted in this article for each electric field driven pumping mechanism. The detailed understanding of these phenomena and relevant key parameters are critical for better utilization, modulation, and selection of appropriate phenomenon for efficient pumping in a specific microfluidic application.

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Chemoresponsive Nanofluidic Pump That Turns Off in the Presence of Lead Ion

Experton

2018

Anal. Chem.

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There are many applications that require the integration of a pump and a chemical sensor so that the solution being pumped can be analyzed in real time for a specific chemical species and the flow adjusted according to the measured concentration of that species. We describe here an alternative strategy: a chemoresponsive pump where a single device acts as both the sensor and pump simultaneously. We demonstrate this concept with a nanofluidic Pb-responsive pump that uses electroosmotic flow as the pumping technology, and a Pb-binding ionophore that allows the device to selectively respond to Pb. The pump yields high flow rates at low Pb concentrations (<1 μM), but flow rate decreases with concentrations above this threshold and ultimately goes to zero at concentrations above 100 μM.

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Electroosmotic Flow Pump

Cited by 6 publications

References 60 publications

“Connecting worlds – a view on microfluidics for a wider application”

“Connecting worlds – a view on microfluidics for a wider application”

Review: Electric field driven pumping in microfluidic device

Chemoresponsive Nanofluidic Pump That Turns Off in the Presence of Lead Ion

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