Electroosmotic Pumping of Organic Solvents and Reagents in Microfabricated Reactor Chips

Salimi-Moosavi, Hossein; Tang, and Thompson; Harrison, David

doi:10.1021/ja971735f

Cited by 148 publications

(95 citation statements)

References 19 publications

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“…Transport of reactant and product solutions occurred by applying a constant and controlled voltage through the electroosmotic flow (EOF). [160,161] It was found that the yield and the E/Z isomer ratio of the olefin could be optimized through the change of the relative concentration of the reactants and the aimed variation of the concentration gradient. With an aldehyde-to-phosphonium-salt ratio of 2:1 the yield in the microstructured reactor increased from 60 % to 70 % as compared to a conventional batch synthesis.…”

Section: Methodsmentioning

confidence: 99%

Chemistry in Microstructured Reactors

et al. 2004

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The application of microstructured reactors in the chemical process industry has gained significant importance in recent years. Companies that offer not only microstructured reactors, but also entire chemical process plants and services relating to them, are already in existence. In addition, many institutes and universities are active within this field, and process-engineering-oriented reviews and a specialized book are available. Microstructured systems can be applied with particular success in the investigation of highly exothermic and fast reactions. Often the presence of temperature-induced side reactions can be significantly reduced through isothermal operations. Although microstructured reaction techniques have been shown to optimize many synthetic procedures, they have not yet received the attention they deserve in organic chemistry. For this reason, this Review aims to address this by providing an overview of the chemistry in microstructured reactors, grouped into liquid-phase, gas-phase, and gas-liquid reactions.

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Section: Methodsmentioning

confidence: 99%

Chemistry in Microstructured Reactors

et al. 2004

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“…Salimi-Moosavi et al 52 have demonstrated the synthesis of diazo dyes within a micro reactor. The authors have reacted 4-nitrobenzenediazonium tetra¯uoroborate 1 with N,Ndimethylaniline 2 in a micro reactor fabricated from glass, to give the red diazo compound 3 (Scheme 1).…”

Section: Liquid Phase Reactionsmentioning

confidence: 99%

Micro reactors: principles and applications in organic synthesis

et al. 2002

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“…First, the electroosmotic driving force can be applied only to aqueous solutions or to a few polar solvents. [19][20][21] Moreover, applying an electric field causes spatial inhomogenization of the components, owing to a difference in the mobility; this could lead to a spatial change in the sample composition during transportation under a high electric field, although this effect is necessary for electrophoresis analyses. There are usually multi-components in a sample solution, and each component has a characteristic mobility.…”

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confidence: 99%

Integration of Flow Injection Analysis and Zeptomole-Level Detection of the Fe(II)-o-Phenanthroline Complex

et al. 1999

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Microchannels having a 150×100 µm cross section were fabricated in a quartz glass chip as a component in an integrated flow injection analysis (FIA) system. They were put to use for flow, mixing, reaction, and detection. The reaction system was a chelating reaction of divalent iron ion with o-phenanthroline (o-phen), and a photothermal microscope was applied for the ultra-sensitive detection of the non-fluorescent reaction product. Nano liter levels of solutions were introduced and transported by capillary action and mixed by molecular diffusion. Zeptomole levels of the reaction product were detected quantitatively. This was the first demonstration of an on-chip chemical determination device which integrates the primitive FIA system without using electroosmotic liquid control or fluorometric determination.

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Electroosmotic Pumping of Organic Solvents and Reagents in Microfabricated Reactor Chips

Cited by 148 publications

References 19 publications

Chemistry in Microstructured Reactors

Chemistry in Microstructured Reactors

Micro reactors: principles and applications in organic synthesis

Integration of Flow Injection Analysis and Zeptomole-Level Detection of the Fe(II)-o-Phenanthroline Complex

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