Objectives: Analysis of Cassion nanofluid over a wedge is carried out for magnetohydrodynamics (MHD), wedge parameter, thermal radiation parameter, non-uniform heat source or sink and suction/injection parameter. Method: With the help of similarity transformations, the governing partial differential equations corresponding to the momentum and heat transfer are reduced to a set of non-linear ordinary differential equations. Numerical solutions of these equations are obtained. Findings: The influence of relevant parameters on non-dimensional velocity and temperature profiles are depicted graphically and in table form for two flow cases namely for nanofluid and for regular fluid. Novelty: It is experienced that with an escalation of magnetic field parameter, the flow is accelerated. Velocity profile shows growth with enhanced wedge parameter. Nusselt number and Skin friction parameters are discussed with the assistance of the table for base fluid and nanofluid. Keywords: Nanofluid, Suction, Injection, MHD, Casson fluid, Wedge