Electrophoresis of bovine erythrocyte sialic acids: Existence of additional band in trypanotolerant Ndama cattle

Esievo, K. A. N.; Jaye, and Andrew A.; Andrews, J. J. N.; Ukoha, A. I.; Alafiatayo, Ruth; Eduvie, L.O.; Saror, D.I.; Njoku, C.O.

doi:10.1016/s0021-9975(08)80157-0

Cited by 26 publications

(13 citation statements)

References 11 publications

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“…Esievo et al (1982) reported a decline in the amount of sialic acid on the erythrocyte surface in cattle infected with T. vivax leads to anemia because of the process described above. Esievo et al (1986Esievo et al ( , 1990 showed that in N'Dama cattle, concentrations of sialic acid on the erythrocyte surface are higher than in zebu cattle. Because the amount of sialidase and its subsequent hydrolysis is proportional to the concentration of trypanosomes, it has been hypothesized that N'Dama cattle might require a larger number of trypanosomes to reach the same level of erythrocyte damage.…”

Section: Control Of Infection By Immune Responsementioning

confidence: 99%

Trypanosoma (Duttonella) vivax: its biology, epidemiology, pathogenesis, and introduction in the New World - a review

Osório

Madruga

Desquesnes

et al. 2008

Mem. Inst. Oswaldo Cruz

171

121

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Section: Control Of Infection By Immune Responsementioning

confidence: 99%

Trypanosoma (Duttonella) vivax: its biology, epidemiology, pathogenesis, and introduction in the New World - a review

Osório

Madruga

Desquesnes

et al. 2008

Mem. Inst. Oswaldo Cruz

171

121

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“…The observation of hyperactivated macrophages and erythrophagocytosis in tissues of infected cattle [7] suggests that they may be a major cause of anaemia and haemophagocytic syndrome [4]. However, evidence has been provided for the contribution of other mechanisms in different host-parasite combinations, such as haemolysins (reviewed in [6]), differences in type and amounts of sialic acids [8], [9], binding of autologous or polyreactive antibodies or complement C3 to erythrocyte surfaces [10]–[12] or the passive absorption of trypanosome molecules in the erythrocyte membrane [13]. Yet, immunological competence is not essential for the development of anaemia.…”

Section: Introductionmentioning

confidence: 99%

Mechanisms Controlling Anaemia in Trypanosoma congolense Infected Mice

et al. 2009

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Background Trypanosoma congolense are extracellular protozoan parasites of the blood stream of artiodactyls and are one of the main constraints on cattle production in Africa. In cattle, anaemia is the key feature of disease and persists after parasitaemia has declined to low or undetectable levels, but treatment to clear the parasites usually resolves the anaemia.Methodology/Principal FindingsThe progress of anaemia after Trypanosoma congolense infection was followed in three mouse strains. Anaemia developed rapidly in all three strains until the peak of the first wave of parasitaemia. This was followed by a second phase, characterized by slower progress to severe anaemia in C57BL/6, by slow recovery in surviving A/J and a rapid recovery in BALB/c. There was no association between parasitaemia and severity of anaemia. Furthermore, functional T lymphocytes are not required for the induction of anaemia, since suppression of T cell activity with Cyclosporin A had neither an effect on the course of infection nor on anaemia. Expression of genes involved in erythropoiesis and iron metabolism was followed in spleen, liver and kidney tissues in the three strains of mice using microarrays. There was no evidence for a response to erythropoietin, consistent with anaemia of chronic disease, which is erythropoietin insensitive. However, the expression of transcription factors and genes involved in erythropoiesis and haemolysis did correlate with the expression of the inflammatory cytokines Il6 and Ifng.Conclusions/SignificanceThe innate immune response appears to be the major contributor to the inflammation associated with anaemia since suppression of T cells with CsA had no observable effect. Several transcription factors regulating haematopoiesis, Tal1, Gata1, Zfpm1 and Klf1 were expressed at consistently lower levels in C57BL/6 mice suggesting that these mice have a lower haematopoietic capacity and therefore less ability to recover from haemolysis induced anaemia after infection.

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“…the O-acetylated derivatives are resistant to enzymic cleavage and for such sialic acid types, higher amounts of neuraminidase are required to cleave them from the erythrocytes of infected animals to cause anaemia. [10][11][12] Some indigenous Nigerian poultry species have been reported to harbour the velogenic strain of NDV and yet remain apparently healthy, with no obvious anaemia. 13,14 The indigenous Nigerian animal species are more resistant to infectious disease agents than their exotic counterparts, [15][16][17] a feature attributed to genetic resistance.…”

Section: Introductionmentioning

confidence: 99%

Comparative studies on erythrocyte sialic acid levels in apparently healthy indigenous Nigerian poultry species

Useh

Omeiza

Nok

et al. 2006

Cell Biochem. Funct.

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The erythrocyte surface sialic acid levels of 200 apparently healthy indigenous Nigerian poultry species (pigeons, guinea fowls, ducks and chickens, n = 50 for each species) presented for slaughter at a poultry abattoir in Zaria, Nigeria was determined. Other parameters determined were packed cell volume (PCV) and plasma total protein (TP) concentration. The mean erythrocyte surface sialic acid concentration of pigeons, guinea fowls, ducks and chickens were 7.88 +/- 2.51, 14.6 +/- 2.51, 17.6 +/- 2.51 and 14.2 +/- 2.51 mg mg(-1) respectively. There was a statistically significant difference between the mean erythrocyte surface sialic acid concentration of all the species of poultry sampled (P < 0.05). The high erythrocyte surface sialic acid concentration in the indigenous Nigerian poultry species could be responsible for their resistance to infectious diseases, whose aetiologic agents produce neuraminidases. The mean PCV of the pigeons, guinea fowls, ducks and chickens were 46.22 +/- 6.91, 38.24 +/- 6.91, 36.50 +/- 6.91 and 36.46 +/- 6.91% respectively. The difference between the mean PCV values of pigeons on the one hand and guinea fowls, ducks and chickens on the other was statistically significant (P < 0.05). A negative correlation (r = -0.36, P < 0.05) between mean erythrocyte surface sialic acid concentrations and PCV was observed, i.e. the birds with the highest mean PCV values had the lowest levels of erythrocyte surface sialic acid. There was no correlation between TP concentration and either erythrocyte surface sialic acid concentration or PCV values. It is suggested, based on this study, that erythrocyte sialic acid types in these species should be determined, as the results may be vital in selective breeding.

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Electrophoresis of bovine erythrocyte sialic acids: Existence of additional band in trypanotolerant Ndama cattle

Cited by 26 publications

References 11 publications

Trypanosoma (Duttonella) vivax: its biology, epidemiology, pathogenesis, and introduction in the New World - a review

Trypanosoma (Duttonella) vivax: its biology, epidemiology, pathogenesis, and introduction in the New World - a review

Mechanisms Controlling Anaemia in Trypanosoma congolense Infected Mice

Comparative studies on erythrocyte sialic acid levels in apparently healthy indigenous Nigerian poultry species

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