1998
DOI: 10.1016/s0301-4622(98)00093-3
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Electrophoresis of long DNA molecules in linear polyacrylamide solutions

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Cited by 49 publications
(56 citation statements)
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References 41 publications
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“…3,57 U-shape or V-shape conformation has also been found in other simulation studies. 14,15 Figure 4 shows the time development variation of the x component of the DNA end-to-end distance X end and the maximum bead-bead distance within the DNA chain in the x direction X max , respectively.…”
Section: Ion Distribution Patternsupporting
confidence: 81%
See 1 more Smart Citation
“…3,57 U-shape or V-shape conformation has also been found in other simulation studies. 14,15 Figure 4 shows the time development variation of the x component of the DNA end-to-end distance X end and the maximum bead-bead distance within the DNA chain in the x direction X max , respectively.…”
Section: Ion Distribution Patternsupporting
confidence: 81%
“…[1][2][3][4] Significant progress has been made in developing simulation models of DNA and protein electrophoresis in nanofluidic devices and other systems primarily using implicit solvent methods. For example, the bond-fluctuation Monte-Carlo method has been used for simulating the motion of long polyelectrolytes inside an array of microscopic traps.…”
Section: Introductionmentioning
confidence: 99%
“…We immediately see that on average, the DNA adopt extended so-called ''I-shape'' configurations and traverse the pores in the same manner as observed in concentrated agarose or polyacrylamide solutions. 15,48,49 This is best seen by observing the third, fourth, and fifth images of Fig. 5a.…”
mentioning
confidence: 84%
“…A series of videomicroscopy studies [17,[40][41][42][43][44][45] of large linear DNA in polymer solutions has revealed that the DNA molecule undergoes significant conformational changes during electrophoretic migration. Carlsson et al [43] and Morris and co-workers [44,45] in their visualization studies found that, although the dynamics of DNA migrating through polymer solutions have some characteristics similar to that of DNA migrating in gels, the apex of the U-shape conformation for linear DNA migrates in polymer solution whereas in gels the apex remains stationary.…”
Section: Videomicroscopymentioning
confidence: 99%