Electrophoretic characterization of LNP/AAV‐encapsulated nucleic acids: Strengths and weaknesses
Andrei Hutanu,
Miriam López Ferreiro,
Joost van Haasteren
et al.
Abstract:The use of nucleic acids (NAs) has revolutionized medical approaches and ushered in a new era of combating various diseases. Accordingly, there is an increasing demand for accurate identification, localization, quantification, and characterization of NAs encapsulated in nonviral or viral vectors. The vast spectrum of molecular dimensions and intra‐ and intermolecular interactions presents a formidable obstacle for NA analytical development. Typically, the comprehensive analysis of encapsulated NAs, free NAs, a… Show more
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