Electrophoretic Deposited Stable Chitosan@MoS₂ Coating with Rapid In Situ Bacteria‐Killing Ability under Dual‐Light Irradiation

Abstract

Developing in situ disinfection methods in vivo to avoid drug-resistant bacteria and tissue toxicity is an urgent need. Here, the photodynamic and photothermal properties of the chitosan-assisted MoS (CS@MoS ) hybrid coating are simultaneously inspired to endow metallic Ti implants with excellent surface self-antibacterial capabilities. This coating, irradiated by only 660 nm visible light (VL) for 10 min, exhibits an antibacterial efficacy of 91.58% and 92.52% against Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus), respectively. The corresponding value is 64.67% and 57.44%, respectively, after irradiation by a single 808 nm near infrared light for the same amount of time. However, the combined irradiation using both lights can significantly enhance the efficiency up to 99.84% and 99.65% against E. coli and S. aureus, respectively, which can be ascribed to the synergistic effects of photodynamic and photothermal actions. The former produces single oxygen species under 660 nm VL while the latter induces a rise in temperature of implants, which can inhibit the growth of both E. coli and S. aureus. The introduction of CS can also promote the biocompatibility of implants, which provides a facile, rapid, and safe in situ bacteria-killing method in vivo without needing a second surgery.

Functionalized MoS2 Nanovehicle with Near‐Infrared Laser‐Mediated Nitric Oxide Release and Photothermal Activities for Advanced Bacteria‐Infected Wound Therapy

“…As shown in Figure D, the as‐prepared MoS 2 ‐α‐CD exhibited a similar spectrum to that of α‐CD while the MoS 2 ‐BNN6 exhibited similar spectrum to that of BNN6. The peaks at 3430 and 1640 cm −1 can be assigned to the stretching of OH, and the bands from 1000 to 1200 cm −1 resulted from skeletal vibrations of COC stretching . These groups were attributed to α‐CD.…”

Responsive and Synergistic Antibacterial Coatings: Fighting against Bacteria in a Smart and Effective Way

“…It is found that most of PTAs yield the photothermal effect only under the NIR band, while most of PSs produce ROS under the visible light spectrum. Therefore, in the systems containing both PTAs and PSs, dual‐light irradiation is one direct approach for performing APTT and APDT at the same time . However, killing bacteria using UV–vis irradiation may not be desired in vivo due to its damage to biological tissues.…”

Highly Effective and Noninvasive Near‐Infrared Eradication of a Staphylococcus aureus Biofilm on Implants by a Photoresponsive Coating within 20 Min

“…Moreover, reactive oxygen species (ROS) has been reported to induce bacteria death through the initial oxidative lesions effect on cell membrane and wall. In this study, we proposed a synergistic exogenous antimicrobial system composed of MoS 2 , IR780, and arginine-glycine-aspartic acid-cysteine (RGDC), in which MoS 2 is a biocompatible prototypical transition-metal dichalcogenide that exhibits high photothermal conversion efficiency, [30][31][32][33] while IR780 is a photosensitizer that can transfer the energy of near-infrared (NIR) light to dissolved oxygen ( 3 O 2 ) to generate singlet oxygen ( 1 O 2 ). [28,29] Multiple synergetic antibacterial modalities are considered promising approaches to induce potent synergistic effect and decrease the side effect of single modality.…”