Electrophoretic examination of human cervical mucus from normal, pregnant and carcinomatous patients

Spencer, B. F.; Sunseri, Linda Z.; Sunseri, S.G.

doi:10.1016/0009-8981(57)90050-5

Cited by 6 publications

(1 citation statement)

References 8 publications

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“…which is predominant in most other secretions has been also demonstrated in cer vical mucus [8,9,10]. Besides immunoglobulins, chemical analysis of human cervico-vaginal secretions has revealed the presence of albumin, lactoferrin, blood group substances, glycoproteins of mucin class [9,10,11,12,13,14] as well as various enzymes such as lysozyme [15] and mucopolysaccharidase [11],…”

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confidence: 99%

Some Immunological Properties of Human Cervical and Vaginal Secretions

J¹,

Jp²

1972

Gynecol Obstet Invest

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The cervico-vaginal secretions of 58 women were shown to contain IgG and IgA globulins in high concentration. The ratio IgG/IgA was found to be 1.5. IgM globulin was demonstrated only occasionally. Agglutinating antibodies to Candida albicans were present in 48% of the samples and antibodies to E.Coli in 77%. The opsonizing property of genital tract secretions against Enterococcus, Kleb-siella, Proteus vulgaris and Pseudomonas was found to be present in 207 tests (79%). Absorption of the material with a rabbit anti-human y-globulin anti-serum removed almost all the opsonizing activity. Lysozyme and complement were shown to enhance the phagocytic properties of these external secretions. Local immunological mechanisms are likely to play a significant role in the protection of human genital tract against infection.

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