Electrophoretic identification of serum immunoglobulins linked to amylase: Macroamylase

Overlapping Presence of Macroamylasemia and Hyperamylasemia in Acute Pancreatitis

“…One of the predisposing conditions for macroamylasemia is a polyclonal increase in immunoglobulins (Ig). Some studies have reported that macroamylasemia may decrease or resolve when these underlying diseases are treated, and that the risk for autoimmune or lymphoproliferative diseases is higher in macroamylasemia with light-chain restriction in Ig-enzyme complexes [2, 9]. …”

“…Complex formation with IgA-type immunoglobulins was reported in 92% of the patients with macroamylasemia [2, 9]. Liver cirrhosis is known to be a condition that increases IgA production through the following mechanism: Serum albumin concentrations are greatly reduced by increased albumin degradation as well as decreased synthesis.…”