Electrophoretic Studies of the Serum Proteins in Virus Hepatitis

Abnormally Low α2‐ and β‐Globulin Levels in Serious Hepatic Insufficiency

“…According to most authors the following changes are seen: decrease in albumin, rise in y-globulins, and sometimes ararely largeincrease in 1-globuliris (Franklin et al 1951). Occasionally electrophoretic patterns have been described which are like those of our patients (Ricketts and Sterling 1949;Janssen and Verschure 1951;Popper et 01. 195 1 ;Staub 1947;Satoskar and Gaitonde 1954;Charbonnier, Baesens and Caroli 1953).…”

Electrophoretic Studies in Liver Disease. Ii. Gamma1 Globulin in Chronic Liver Disease 12

“…The elevation of the gamma1 globulin component in chronic liver disease and the slight elevation in acute types of hepatic damage might appear to suggest typical antibody response such as is seen in infections in which antibodies increase as the condition becomes chronic. However, previous studies (39) have shown that scarring following viral hepatitis may occur with decreasing concentrations of electrophoretically separated gamma globulin. Viral hepatitis, the only hepatic condition in this study definitely known to be infectious, strangely enough showed little rise in the gammal fraction.…”

Electrophoretic Studies of the Plasma and Serum Proteins in Sickle Cell Anemia 1

“…It is now generally agreed that abnormal electrophoretic patterns are not specific for definite disease processes, with the exception of some cases of multiple myeloma and lipoid nephrosis (8)(9)(10). The abnormalities described here are relatively common in a variety of diseases, but are most consistently present in diseases associated with hepatic dysfunction such as acute hepatitis (11,12), cirrhosis of the liver (13)(14)(15), and infectious mononucleosis (16). There has been good correlation in these diseases with a positive cephalin flocculation (17), and it is interesting that this test was positive 3 or 4 plus in the majority of our patients on whom the test was done.…”