Electrophoretically prepared hybrid materials for biopolymer hydrogel and layered ceramic nanoparticles

Abstract

BackgroundIn order to obtain biomaterials with controllable physicochemical properties, hybrid biomaterials composed of biocompatible biopolymers and ceramic nanoparticles have attracted interests. In this study, we prepared biopolymer/ceramic hybrids consisting of various natural biopolymers and layered double hydroxide (LDH) ceramic nanoparticles via an electrophoretic method. We studied the structures and controlled-release properties of these materials.Results and discussionX-ray diffraction (XRD) patterns and X-ray absorption spectra (XAS) showed that LDH nanoparticles were formed in a biopolymer hydrogel through electrophoretic reaction. Scanning electron microscopic (SEM) images showed that the ceramic nanoparticles were homogeneously distributed throughout the hydrogel matrix. An antioxidant agent (i.e., ferulic acid) was loaded onto agarose/LDH and gelatin/LDH hybrids, and the time-dependent release of ferulic acid was investigated via high-performance liquid chromatography (HPLC) for kinetic model fitting.ConclusionsBiopolymer/LDH hybrid materials that were prepared by electrophoretic method created a homogeneous composite of two components and possessed controllable drug release properties according to the type of biopolymer.

The Efficacy of Electron Beam Irradiated Bacterial Cellulose Membranes as Compared with Collagen Membranes on Guided Bone Regeneration in Peri-Implant Bone Defects

“…In particular, the 3D structure of CM is similar to that of BC [ 12 , 13 , 14 , 15 ]. According to mechanical analysis, the EI process does not change the thickness or nanoporous network structure of BCMs [ 53 ], but the high energy electron beams cleave D-glucose chains resulting in cleavage of nanofibers [ 54 ]. The porosity of BC can be altered by metabolic source and culture conditions [ 1 ].…”

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Recent approaches in designing bioadhesive materials inspired by mussel adhesive protein

“…Controlling interfacial adsorption of biomolecules, proteins, and cells greatly affects the success of implanted biomaterials 262. Immobilizing antifouling polymers such as PEG on device surfaces is a common strategy to reduce nonspecific adsorption of cells and proteins 73, 185.…”

Bioengineering of Humanized Bone Marrow Microenvironments in Mouse and Their Visualization by Live Imaging

“…Merging biomaterials and cell-implantation concepts, reports have shown the feasibility of mimicking the human bone marrow microenvironment in heterotopic regions 23 24 25 26 27 . This opens the possibility of using bioengineering in mouse models to study human normal and malignant hematopoiesis 28 29 30 31 32 33 34 35 36 37 38 39 , tumorigenesis, and metastasis 40 41 42 43 44 .…”