Electrophysiologic and Retinal Penetration Studies Following Intravitreal Injection of Bevacizumab (Avastin)

Abstract

Bevacizumab was found to be nontoxic to the retina of rabbits based on electrophysiologic studies. Full thickness retinal penetration may explain observed clinical effects of intravitreal bevacizumab. Although it is difficult to directly extrapolate to humans, our study supports the safe use of intravitreal bevacizumab injection.

Intravitreal triamcinolone acetonide vs bevacizumab for treatment of macular oedema secondary to branch retinal vein occlusion

“…[37][38][39][40][41][42][43] Intravitreal triamcinolone acetonide treatment may lead to complications, such as ocular hypertension, cataract progression, retinal detachment, intraocular haemorrhage, and infectious endophthalmitis. The most common side effect reported after intravitreal injection of triamcinolone acetonide is the risk of IOP elevation.…”

Intravitreal triamcinolone acetonide vs bevacizumab for treatment of macular oedema due to central retinal vein occlusion

“…[29][30][31][32][33][34][35] The most common side effect reported after intravitreal injection of triamcinolone acetonide is the risk of IOP elevation. 13,14,17 In this study, seven of 22 CRVO patients without preexisting glaucoma developed steroid-induced elevated IOP after intravitreal triamcinolone acetonide injection and six were controlled with topical antiglaucomatous medication but one needed trabeculectomy.…”

Intravitreal bevacizumab in pigmented rabbit eyes: histological analysis 90 days after injection

“…In vitro studies have shown that doses higher than 1.25 mg bevacizumab can be deleterious to RPE cells (13)(14) . Bevacizumab quickly reaches the subretinal space after an intravitreal application, therefore, the photoreceptor layer and the RPE could be at risk (12,21) . However, pigmented rabbits were used only in a few studies found in the pertinent literature, whose follow-up was also shorter than 4 weeks (22)(23) .…”