Electrophysiologic Effects of Enflurane and Halothane on Isolated Rabbit Hearts in the Presence and Absence of Metabolic Acidosis

Ozaki, Suzuko; Gotoh, Yasuyuki; Nakaya, Haruaki; Azuma, Mitsue; Kanno, Morio

doi:10.1213/00000539-198511000-00004

Cited by 5 publications

(3 citation statements)

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“…Electrophysiological studies with inhalation anaesthetics demonstrated that halothane and enflurane were more depressant of A-V nodal conduction time than isoflurane [36][37][38] . However, the electrophysiological effects of sevoflurane have not been studied fully.…”

Section: Discussionmentioning

confidence: 99%

Atrioventricular conduction during adenosine-induced hypotension in dogs anaesthetized with sevoflurane

Ishii¹,

Akazawa²,

Shimizu³

et al. 1996

British Journal of Anaesthesia

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We have studied the effects of adenosine-induced hypotension on A-H interval (atrioventricular (AV) nodal conduction time during sinus rhythm), St-H interval (intra-atrial plus AV nodal conduction time during atrial pacing), H-V interval (His-Purkinje conduction time) and H-S interval (total ventricular conduction time) by His-bundle electrocardiography in addition to surface electrocardiogram during both sinus rhythm and atrial pacing in nine dogs anaesthetized with 1 MAC of sevoflurane. Stepwise increases in infusion rates of adenosine to 0.1, 0.3, 0.5 and 1.0 mg kg-1 min-1 produced a dose-related decrease in mean arterial pressure from 91 (6) to 38 (2) mm Hg. Adenosine significantly increased the A-H interval at infusion rates of 0.5 mg kg-1 min-1 and above, and the St-H interval at 1.0 mg kg-1 min-1. The H-V and H-S intervals remained unchanged. Heart rate decreased significantly only at 1.0 mg kg-1 min-1 with a significant increase in the PR interval. Adenosine-induced hypotension did not have deleterious effects on AV conduction times and the surface electrocardiogram in dogs anaesthetized with 1 MAC of sevoflurane. This may indicate that the effects of adenosine on AV conduction were small and therefore are unlikely to be a contraindication to the use of adenosine for inducing hypotension in patients with initially normal conduction during sevoflurane anaesthesia.

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Section: Discussionmentioning

confidence: 99%

Atrioventricular conduction during adenosine-induced hypotension in dogs anaesthetized with sevoflurane

Ishii¹,

Akazawa²,

Shimizu³

et al. 1996

British Journal of Anaesthesia

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“…It has been recognized that halothane and enflurane slow the discharge of the sinoatrial node and the conduction of the atrioventricular node (1)(2)(3)(4)(5)(6)(7). In addition, these anesthetics sensitize the heart to catecholamines and cause ventricular tachyarrhythmias in the presence of adrenergic agonists (8)(9)(10).…”

mentioning

confidence: 99%

“…We previously reported that halothane and enflurane impair not only the atrioventricular conduction but also intraventricular conduction (7). Our recent study using conventional microelectrode techniques (13) has suggested that these volatile anesthetics impair the intraventricular conduction by mechanism(s) different from those involving fast sodium channel blockers such as lidocaine or tetrodotoxin.…”

mentioning

confidence: 99%

Effects of Isoflurane on Conduction Velocity and Maximum Rate of Rise of Action Potential Upstroke in Guinea Pig Papillary Muscles

Ozaki

Nakaya

Gotoh

et al. 1990

Anesthesia & Analgesia

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This study was undertaken to determine whether isoflurane, a volatile anesthetic that is reported to possess a wide margin of cardiovascular safety, exerts electrophysiological effects on cardiac tissue. By use of standard microelectrode techniques, effects of isoflurane on the maximum rate of rise of action potential upstroke (Vmax) and conduction velocity were examined in guinea pig papillary muscles. Isoflurane decreased action potential amplitude and action potential duration in a concentration-dependent fashion. Isoflurane at 1.5 and 2.0 MAC decreased conduction velocity with as little influence on the maximum rate of rise of action potential upstroke as that exerted by halothane and enflurane. However, the effect of isoflurane in slowing intraventricular conduction was less than that of halothane and enflurane when compared at equi-MAC concentrations. Thus, isoflurane may be a safer anesthetic for the patients with intraventricular conduction abnormalities.

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Mécanismes compensateurs et conséquences de l'acidose métabolique

Scemama

1986

Annales Françaises d'Anesthésie et de Réanimation

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Electrophysiologic Effects of Enflurane and Halothane on Isolated Rabbit Hearts in the Presence and Absence of Metabolic Acidosis

Cited by 5 publications

References 0 publications

Atrioventricular conduction during adenosine-induced hypotension in dogs anaesthetized with sevoflurane

Atrioventricular conduction during adenosine-induced hypotension in dogs anaesthetized with sevoflurane

Effects of Isoflurane on Conduction Velocity and Maximum Rate of Rise of Action Potential Upstroke in Guinea Pig Papillary Muscles

Mécanismes compensateurs et conséquences de l'acidose métabolique

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