Electrophysiological analysis of pathways connecting the medial preoptic area with the mesencephalic central grey matter in rats.

Macleod, Neil; Mayer, Mark L.

doi:10.1113/jphysiol.1980.sp013066

Cited by 52 publications

(9 citation statements)

References 44 publications

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“…1 A, B) in 26 % of medial preoptic neurones examined in rats anaesthetized with urethane. Such responses occurred over a variable range of latencies (mean 12-7, median 9 7 ms) and duration (mean 51P7, median 42-4 ms), as reported previously (MacLeod & Mayer, 1980 57X2 ms) occurred in the majority of neurones examined for such a response (Fig. 1 E,F).…”

Section: Inhibitory Synaptic Responsesmentioning

confidence: 60%

“…Stimulation of the periaqueductal grey was less effective in evoking synaptic excitation and subsequent inhibition. Neurones invaded antidromically from the periaqueductal grey were not usually inhibited by single stimuli just subthreshold for antidromic invasion, although trains of stimuli were more often effective (see MacLeod & Mayer, 1980). PREOPTIC AREA INHIBITORY MECHANISMS longer latency responses to periaqueductal grey stimulation.…”

Section: Inhibitory Synaptic Responsesmentioning

confidence: 99%

“…Stimulus pulses of 300500 us width, 250-850 ,sA intensity, were applied with photon-coupled stimulus isolation units programmed 328 PREOPTIC AREA INHIBITORY MECHANISMS .by a Hivotronics clock. The arcuate-ventromedial area was stimulated at 1 Hz, the periaqueductal grey with trains of three pulses at 100 Hz repeated every second (MacLeod & Mayer, 1980). Extracellular single unit activity was sampled with glass micropipettes, tip diameter < 1 pm, and resistance 5-10 MCI when filled with 4 M-sodium chloride.…”

Section: Stimulation and Recordingmentioning

confidence: 99%

“…Inhibitory synaptic responses in the preoptic-anterior hypothalamus may be evoked following stimulation of the arcuate-ventromedial hypothalamic nuclei (Dyer, 1973;Fenske, Ellendorff & Wuttke, 1975;MacLeod & Mayer, 1980), the amygdala Fenske et al 1975;Gardner & Phillips, 1977 a) and the periaqueductal grey (MacLeod & Mayer, 1980). The neuronal circuitry involved in generating such inhibitory responses remains unknown, but both and Gardner & Phillips (1977b) have suggested the involvement of local circuit interneurones.…”

Section: Introductionmentioning

confidence: 99%

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Electrophysiological analysis of inhibitory synaptic mechanisms in the preoptic area of the rat.

Mayer¹

1981

The Journal of Physiology

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Micro-injection of tetanus toxin (100-200 MLD) into the preoptic-anterior hypothalamus signficantly reduced the frequency ofoccurrence ofinhibition evoked from both sites.6. Pentobarbitone administered acutely or as the sole anaesthetic increased both the duration and frequency of occurrence of inhibitory responses evoked from the arcuate-ventromedial nuclei.7. It is suggested that a GABA-linked inhibitory synaptic mechanism, activated by arcuate-ventromedial and periaqueductal grey stimulation, operates in the preoptic-anterior hypothalamus. Such convergent inhibition may be a result of activity in local interneurone circuitry.

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Section: Inhibitory Synaptic Responsesmentioning

confidence: 60%

Section: Inhibitory Synaptic Responsesmentioning

confidence: 99%

Section: Stimulation and Recordingmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Electrophysiological analysis of inhibitory synaptic mechanisms in the preoptic area of the rat.

Mayer¹

1981

The Journal of Physiology

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“…Indeed, there are dense reciprocal connections between the mPOA and the cPAG l,vl Swanson, 1986, 1988;Rizvi et al, 1992), and neuronal activity in the mPOA is inhibited after stimulation of the ventral PAG (MacLeod and Mayer, 1980). The cPAG l,vl , however, does not fully control suckling-induced inactivity, because dams with lesions in this site eventually became quiescent while nursing in another posture; therefore, larger lesions than the very discrete ones imposed in the present studies may be needed to prevent suckling-induced inhibition of movement.…”

Section: Role Of the Cpag In Kyphosismentioning

confidence: 99%

Role of the Midbrain Periaqueductal Gray in Maternal Nurturance and Aggression:c-fosand Electrolytic Lesion Studies in Lactating Rats

1997

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The upright crouched, or kyphotic, nursing posture of lactating rats is dependent on suckling stimulation from pups. Because of the neuroanatomical connections of the periaqueductal gray (PAG) and its sensorimotor integration of the analogous lordosis posture displayed by sexually receptive female rats, the possible role of the PAG in kyphosis was investigated using c-fos immunocytochemistry and electrolytic lesions. Lactating rats interacting with and nursing a litter of suckling pups showed greater Fos-immunoreactive nuclei in the lateral and ventrolateral caudal PAG (cPAG l,vl ) compared with dams receiving nonsuckling somatosensory, distal, or no stimulation from pups. In contrast, this pattern was not evident in the rostral PAG, where the highest Fos levels occurred in nonsuckled dams, or in five other brainstem sites with either no group differences (peripeduncular, dorsal raphe, and pontine nuclei) or negligible Fos (ventral tegmental area, spinal trigeminal nuclei). After bilateral electrolytic lesions of the cPAG l,vl during gestation or on day 7 postpartum, active maternal behaviors, such as retrieval and licking of pups, and total nursing time were essentially normal. Kyphotic nursing, however, was reduced by 85%, nursing in prone and supine postures increased substantially, and 24 hr litter weight gains were reduced, particularly early in lactation (by 26%). Furthermore, lesioned rats attacked a strange male twice as often as controls did, which is suggestive of reduced fearfulness. These results extend the known roles of the PAG in reproductive and defensive behaviors to the postural control of suckling-induced kyphotic nursing and the modulation of maternal aggression.

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The organization of neural inputs to the medial preoptic nucleus of the rat

Simerly¹,

Swanson²

1986

J of Comparative Neurology

507

252

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There is general agreement that the medial preoptic nucleus (MPN) receives projections from widespread regions of the brain, although there are significant discrepancies in the literature with regard to certain specific inputs. Therefore, we have reexamined the inputs to this nucleus with both retrograde and anterograde axonal transport techniques. First, injections of the retrograde tracers true blue, SITS, or wheat germ agglutinin were made into the region of the MPN and the distribution of retrogradely labeled cells was charted. Then, autoradiographic material was used to confirm the results of the retrograde studies, to identify the route taken by fibers projecting to the MPN, and to describe the distribution of projections with respect to the three cytoarchitectonic subdivisions of the nucleus. The results indicate that the MPN receives inputs from widely distributed areas in both the forebrain and brainstem, and that these inputs appear to be distributed topographically within the three cytoarchitectonic subdivisions of the nucleus. Direct inputs to the MPN arise from all major areas of the hypothalamus (except for the median and magnocellular preoptic nuclei, the supraoptic and suprachiasmatic nuclei, and the medial and lateral mammillary nuclei). Projections from nuclei within the periventricular zone of the hypothalamus end primarily in the medial part of the MPN, while inputs from the lateral zone are mainly confined to the lateral part of the nucleus, as are projections from the nuclei within the medial zone, except for those from the anterior and ventromedial nuclei, which appear to be more widespread. The MPN receives major inputs from limbic regions including the amygdala, ventral subiculum, and ventral lateral septal nucleus, all of which end preferentially in the lateral part of the MPN. In contrast, the projection from the encapsulated part of the bed nucleus of the stria terminalis appears to end preferentially in the central part of the MPN and in immediately adjacent regions of the medial subdivision. In addition, the MPN may receive relatively sparse inputs from infralimbic and insular cortical areas, the nucleus accumbens, and the substantia innominata. Finally, ascending serotoninergic projections from the raphe nuclei appear to terminate principally in the lateral part of the MPN, whereas inputs from regions containing noradrenergic cell groups are chiefly distributed to the central and medial parts of the nucleus. Other brainstem regions that appear to provide modest inputs include the ventral tegmental area, central tegmental field, periaqueductal gray, pedunculopontine nucleus, and the peripeduncular nucleus.(ABSTRACT TRUNCATED AT 400 WORDS)

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Electrophysiological analysis of pathways connecting the medial preoptic area with the mesencephalic central grey matter in rats.

Cited by 52 publications

References 44 publications

Electrophysiological analysis of inhibitory synaptic mechanisms in the preoptic area of the rat.

Electrophysiological analysis of inhibitory synaptic mechanisms in the preoptic area of the rat.

Role of the Midbrain Periaqueductal Gray in Maternal Nurturance and Aggression:c-fosand Electrolytic Lesion Studies in Lactating Rats

The organization of neural inputs to the medial preoptic nucleus of the rat

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