Electrophysiological and inflammatory changes of CA1 area in male rats exposed to acute kidney injury: Neuroprotective effects of erythropoietin

Tahamtan, Mahshid; Kohlmeier, Kristi A.; Faatehi, Mahdiyeh; Basiri, Mohsen; Shabani, Mohammad

doi:10.1016/j.brainresbull.2021.03.007

Cited by 3 publications

(3 citation statements)

References 43 publications

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“… 41 , 42 A study conducted on acute kidney injury (AKI) found that functional activity was significantly diminished in the hippocampus, a brain region particularly vulnerable to pathological conditions. 43 Temporal analysis of AKI rat models further revealed that ALFF values of the hippocampus decreased at the onset of 48 h after AKI, which was in agreement with the results of the behavioral test. 44 , 45 Our further assessment revealed that the modified intensity of low frequency in the hippocampus could be attributed to impaired neuron function, which is consistent with cognitive behaviors.…”

Section: Discussionsupporting

confidence: 76%

“…The application of amplitude of low‐frequency fluctuations (ALFF) analysis to the whole brain has been used to detect early functional deficits in central nervous system (CNS) diseases 41,42 . A study conducted on acute kidney injury (AKI) found that functional activity was significantly diminished in the hippocampus, a brain region particularly vulnerable to pathological conditions 43 . Temporal analysis of AKI rat models further revealed that ALFF values of the hippocampus decreased at the onset of 48 h after AKI, which was in agreement with the results of the behavioral test 44,45 .…”

Section: Discussionmentioning

confidence: 99%

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Microglia dysfunction drives disrupted hippocampal amplitude of low frequency after acute kidney injury

Pang

Yang

et al. 2023

CNS Neurosci Ther

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AimsAcute kidney injury (AKI) has been associated with a variety of neurological problems, while the neurobiological mechanism remains unclear. In the present study, we utilized resting‐state functional magnetic resonance imaging (rs‐fMRI) to detect brain injury at an early stage and investigated the impact of microglia on the neuropathological mechanism of AKI.MethodsRs‐fMRI data were collected from AKI rats and the control group with a 9.4‐Tesla scanner at 24, 48, and 72 h post administration of contrast medium or saline. The amplitude of low‐frequency fluctuations (ALFF) was then compared across the groups at each time course. Additionally, flow cytometry and SMART‐seq2 were employed to evaluate microglia. Furthermore, pathological staining and Western blot were used to analyze the samples.ResultsMRI results revealed that AKI led to a decreased ALFF in the hippocampus, particularly in the 48 h and 72 h groups. Additionally, western blot suggested that AKI‐induced the neuronal apoptosis at 48 h and 72 h. Flow cytometry and confocal microscopy images demonstrated that AKI activated the aggregation of microglia into neurons at 24 h, with a strong upregulation of M1 polarization at 48 h and peaking at 72 h, accompanying with the release of proinflammatory cytokines. The ALFF value was strongly correlated with the proportion of microglia (|r| > 0.80, p < 0.001).ConclusionsOur study demonstrated that microglia aggregation and inflammatory factor upregulation are significant mechanisms of AKI‐induced neuronal apoptosis. We used fMRI to detect the alterations in hippocampal function, which may provide a noninvasive method for the early detection of brain injury after AKI.

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Section: Discussionsupporting

confidence: 76%

Section: Discussionmentioning

confidence: 99%

Microglia dysfunction drives disrupted hippocampal amplitude of low frequency after acute kidney injury

Pang

Yang

et al. 2023

CNS Neurosci Ther

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“…It has been shown that the number of cells presenting GFAP-positive in the CA1 region of the hippocampus is significantly elevated after ischemia-reperfusion injury of the kidney. This predicts a massive proliferation of astrocytes [ 234 , 235 ]. And as an important component in the cerebral lymphatic system, the proliferation of astrocytes may affect the normal function of the glymphatic system to some extent.…”

Section: The Critical Role Of the Cerebral Lymphatic System As A Brid...mentioning

confidence: 99%

Connecting the Dots: The Cerebral Lymphatic System as a Bridge Between the Central Nervous System and Peripheral System in Health and Disease

Zhao¹,

Sun²,

Zhang³

et al. 2024

Aging and disease

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As a recently discovered waste removal system in the brain, cerebral lymphatic system is thought to play an important role in regulating the homeostasis of the central nervous system. Currently, more and more attention is being focused on the cerebral lymphatic system. Further understanding of the structural and functional characteristics of cerebral lymphatic system is essential to better understand the pathogenesis of diseases and to explore therapeutic approaches. In this review, we summarize the structural components and functional characteristics of cerebral lymphatic system. More importantly, it is closely associated with peripheral system diseases in the gastrointestinal tract, liver, and kidney. However, there is still a gap in the study of the cerebral lymphatic system. However, we believe that it is a critical mediator of the interactions between the central nervous system and the peripheral system.

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The anti-apoptotic and anti-autophagic effects of EPO through PI3K/Akt/mTOR signaling pathway in MAC-T cells

Liu

Zhang

Yue

et al. 2022

Research in Veterinary Science

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Electrophysiological and inflammatory changes of CA1 area in male rats exposed to acute kidney injury: Neuroprotective effects of erythropoietin

Cited by 3 publications

References 43 publications

Microglia dysfunction drives disrupted hippocampal amplitude of low frequency after acute kidney injury

Microglia dysfunction drives disrupted hippocampal amplitude of low frequency after acute kidney injury

Connecting the Dots: The Cerebral Lymphatic System as a Bridge Between the Central Nervous System and Peripheral System in Health and Disease

The anti-apoptotic and anti-autophagic effects of EPO through PI3K/Akt/mTOR signaling pathway in MAC-T cells

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