Electrophysiological assessment of retinal functions by ERG in Ischemia/Reperfusion (I/R) Allium cepa pre-treated mice

Abstract

Retinal disorders are the one of the most challenging and complex degenerative diseases that need to be addressed because of rapid increase in the number of affected individuals. Most of the available treatments strategies are inadequate to exert permanent solution to the patients. Therefore, as an alternative approach we wanted to test the efficacy of Allium cepa(A. cepa) in an Ischemia/Reperfusion (I/R) mouse model. We orally administered the aqueous extract of A. cepa at different dosages 100 mg/kg, 200 mg/kg, 300 mg/kg 24 hrs prior to the surgery. Electroretinogram (ERG) analysis was carried out at 7 day, 21 day, and 28 day after the surgery. ERG recording depicted that A. cepa administration is able to increase the implicit time but not at the statistically significant level for which larger sample size and deeper analysis is required.