Electrophysiological assessment of the brain function in term SGA infants

Özdemir, Özmert Ma; Ergin, Hacer; Şahiner, Türker

doi:10.1016/j.brainres.2009.03.008

Cited by 25 publications

(21 citation statements)

References 29 publications

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“…The data of our study are in agreement with the results of Ozdemir et al [11 ]that showed delayed maturation and lowered amplitude within conventional EEG in term infants born SGA. A recent study by Yerushalmy-Feler et al [12 ]confirms these findings with aEEG data and power spectrum EEG in late preterm born infants.…”

Section: Discussionsupporting

confidence: 83%

“…brain maturation and some medications, but also hypoxia and/or ischemia. Reports referring to pathologic brain morphology in SGA infants show that a reduction of myelination, especially within the hippocampal and periventricular area, is common [11,25,26]. Tolsa et al [27 ]provided evidence that cortical grey matter is significantly reduced in premature infants with IUGR.…”

Section: Discussionmentioning

confidence: 98%

“…However, EEG data on preterm infants with SGA are still scarce. Ozdemir et al [11] showed delayed maturational signs and a decrease in amplitude and frequency levels on conventional EEG in term SGA infants compared to infants born appropriate for gestational age (AGA). Yerushalmy-Feler et al [12 ]recently showed a contribution of intrauterine growth restriction (IUGR) on aEEG bandwidth and a percentage of delta activity in power spectrum analysis of EEG in preterm infants.…”

Section: Introductionmentioning

confidence: 99%

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Being Born Small for Gestational Age Influences Amplitude-Integrated Electroencephalography and Later Outcome in Preterm Infants

Schwindt¹,

Thaller²,

Czaba-Hnizdo³

et al. 2015

Neonatology

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Background: The impact of growth restriction on perinatal morbidity is well known, but electroencephalographic (EEG) data on its influence are still scarce. Objectives: We aimed to analyze the influence of being born small for gestational age (SGA; defined as a birth weight <10th percentile) on the amplitude-integrated EEG (aEEG) score in the first 2 weeks of life in preterm infants born before 30 weeks of gestation, and its impact on later outcome. Methods: aEEG data obtained within the first 2 weeks of life on preterm infants born SGA and before 30 weeks of gestational age (GA) were analyzed retrospectively using a combined score [including background activity, occurrence of sleep-wake cycles (SWC) and suspected seizure activity]. Neurodevelopmental outcome was evaluated at 24 months by means of the Bayley Scales of Infant Development II and a standardized neurological examination. Results: One hundred and thirty-six patients were included (47 SGA and 89 controls). Infants with SGA had abnormal aEEG scores significantly more often (57 vs. 24%, p = 0.002) than infants born appropriate for gestational age (AGA). They also displayed SWC less frequently (65 vs. 96%, p = 0.001), were more likely to develop seizure activity (15 vs. 4%, p = 0.013) and had a normal neurodevelopmental outcome at the age of 2 years less frequently (36.2 vs. 59.6%, p = 0.02). Conclusion: Preterm infants born SGA and before 30 weeks of GA had less optimal scores on early aEEG and a poorer neurodevelopmental outcome at 24 months than the AGA controls.

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Section: Discussionsupporting

confidence: 83%

Section: Discussionmentioning

confidence: 98%

Section: Introductionmentioning

confidence: 99%

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Being Born Small for Gestational Age Influences Amplitude-Integrated Electroencephalography and Later Outcome in Preterm Infants

Schwindt¹,

Thaller²,

Czaba-Hnizdo³

et al. 2015

Neonatology

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“…To date, only two studies have investigated the potential effects of being born preterm and FGR on EEG activity during sleep; 52,53 however, both of these studies were performed in infants, not children. Consistent with our study, higher δ power was observed in infants born preterm FGR compared with control neonates within the first 48 hours of life.…”

Section: Preterm Fgr Childrenmentioning

confidence: 99%

“…Similar to previous studies, 52,53 we chose to analyze EEG power recorded from one central lead. However, recording from one channel does not assess the regional differences among multiple brain regions known to be affected by FGR and preterm birth.…”

Section: Limitationsmentioning

confidence: 99%

Being Born Too Small and Too Early May Alter Sleep in Childhood

Yiallourou

Arena

Wallace

et al. 2017

Sleep

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Study Objectives: Fetal growth restriction (FGR) occurs in up to 10% of pregnancies and is associated with increased risk of prematurity and neurodevelopmental impairment. FGR also alters sleep-state distribution in utero and maturation in infancy. Currently, limited data on the long-term associations of FGR and childhood sleep exist. Accordingly, we assessed the associations between preterm birth and FGR and sleep in children aged 5-12 years.Methods: Seventeen children born preterm and FGR, 15 children born preterm but appropriately grown (appropriate birth weight for gestational age [AGA]), and 20 term AGA children (controls) were studied using overnight polysomnography. Sleep macroarchitecture was assessed using standard criteria, and sleep microarchitecture was assessed using spectral analysis of the electroencephalogram (C4-M1) with total, δ (0.5-3.9 Hz), θ (4.0-7.9Hz), α (8.0-11.9 Hz), σ (12.0-13.9 Hz), and β power (14.0-30 Hz) calculated.Results: For sleep macroarchitecture, preterm FGR children had higher N2% compared with term AGA children (p < .05). Preterm AGA children had reduced total sleep time, NREM%, and sleep efficiency compared with term AGA children (p < .05 for all). For sleep microarchitecture, preterm FGR children had a higher amount of total, δ and α power compared with both groups (p < .05). Sigma and β power was lowest in the preterm AGA group compared with both groups (p < .05 for both).Conclusions: Prematurity and FGR were associated with altered sleep macro-and microarchitecture measures indicative of reduced sleep quantity and quality in childhood. As sleep disturbance can affect both behavior and neurodevelopment in children, sleep in FGR and preterm children warrants further investigation. Keywords: fetal growth restriction, preterm birth, pediatric, EEG spectral analysis, sleep. Statement of SignificanceFetal growth restriction (FGR) is a major obstetric complication affecting up to 10% of pregnancies leading to increased risk of preterm birth and neurodevelopmental impairment. FGR alters the development of sleep in fetal life and infancy; however, few studies have investigated the long-term impact on sleep. This novel study assessed both sleep macro-and microarchitecture in children born preterm and FGR. Being born preterm and FGR was associated with reduced sleep quality, whereas being born preterm with an appropriate birth weight for gestational age was associated with both reduced sleep quantity and quality. This study highlights the potential need for clinical follow-up of sleep and investigation of the effects of poor sleep on neurodevelopment in this population.

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Term Newborns

Zabransky¹

2013

Caring for Children Born Small for Gestational Age

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Electrophysiological assessment of the brain function in term SGA infants

Cited by 25 publications

References 29 publications

Being Born Small for Gestational Age Influences Amplitude-Integrated Electroencephalography and Later Outcome in Preterm Infants

Being Born Small for Gestational Age Influences Amplitude-Integrated Electroencephalography and Later Outcome in Preterm Infants

Being Born Too Small and Too Early May Alter Sleep in Childhood

Term Newborns

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