Electrophysiological Characterization of Neurotropic Activity of Sideritis Tea Volatiles

Identification of eugenol as the major determinant of GABAA-receptor activation by aqueous Syzygium aromaticum L. (clove buds) extract

“…Introduction c-Amino butyric acid (GABA) is a major inhibitory neurotrans-a1b2-subunits (Sahin et al, 2016). Kessler et al also described the GABA A receptor-modulating activity of volatile Sideritis extracts (Kessler et al, 2012) and identified some terpenoid substances from this extracts that are responsible for GABA A -receptor modulation (Kessler et al, 2014). Zaugg et al reported that ethyl acetate extracts of black pepper (Piper nigrum L.) fruits potentiate GABA Areceptor activity (Zaugg et al, 2010).…”