Electrophysiological Effects of Dizocilpine (MK‐801) in Adult Rats Exposed to Ethanol During Adolescence

Criado, José R.; Wills, Derek N.; Walker, Barbara J.; Ehlers, Cindy L.

doi:10.1111/j.1530-0277.2008.00760.x

Cited by 15 publications

(23 citation statements)

References 84 publications

(116 reference statements)

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“…These data suggest an important role of the glutamatergic NMDA system in the generation of the P3 ERP (Ehlers et al, 1992). More recently, we provided evidence of protracted changes in NMDA systems in cortical and hippocampal neurophysiological activity following adolescent ethanol exposure in rats (Criado et al, 2008a). In that study, we showed that MK-801 significantly reduced P3 ERP amplitude and increased P3 ERP latency in control, but not in adolescent rats exposed to ethanol.…”

Section: Discussionmentioning

confidence: 98%

“…However, the consequences of adolescent ethanol exposure on the expression of NMDAR subunits in the cortex and hippocampus in vivo are just beginning to be understood (Sircar and Sircar, 2006; Pascual et al, 2009). Characterizing the effects of adolescent versus adult ethanol exposure on the expression of NMDAR subunits could provide important information on the unique mechanisms that may mediate the neurophysiological consequences of adolescent ethanol exposure previously shown in our laboratory (Slawecki et al, 2004; Criado et al, 2008a, 2008b). The objective of the present study was to determine whether expression of the NR1, NR2A and NR2B subunits in the hippocampus and frontal cortex is influenced by chronic ethanol exposure and/or withdrawal in adolescent versus adult rats.…”

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confidence: 98%

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N-methyl-d-aspartate receptor subunit expression in adult and adolescent brain following chronic ethanol exposure

Pian¹,

Criado²,

Milner³

et al. 2010

Neuroscience

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Substantial evidence suggests that glutamatergic neurotransmission is a critical mediator of the experience-dependent synaptic plasticity that may underlie alcohol dependence. Substance abuse typically begins in adolescence; therefore, the impact of alcohol on glutamatergic systems during this critical time in brain development is of particular importance. The N-methyl-D-aspartate receptor (NMDAR) is involved in developmental mechanisms underlying neuronal differentiation and synaptogenesis and as such may be a target system for alcohol effects during adolescence. In the present study quantitative biochemical determinations were made of the relative abundance of different protein expressions of NMDAR subunits in adolescents and adults after 2 wks of ethanol vapor exposure, and 24 hrs and 2 wks following withdrawal. After 2 wks of ethanol vapor exposure NR1, NR2A, and NR2B subunit expression was found to be increased in hippocampus of the adults. In contrast, 2 wks of ethanol exposure resulted in no significant changes in NR1 and NR2B subunits and a reduction NR2A subunit expression in hippocampus in adolescents. Twenty-four hours and 2 wks following withdrawal from ethanol vapor NR1 and NR2A subunit expression in hippocampus was decreased in adolescents, whereas in adults it had returned to control levels. In frontal cortex, 2 wks of chronic ethanol exposure produced decreases in NR1 subunit expression in both adults and adolescents but also produced decreases in NR2A and NR2B subunit expression in adults that returned or exceeded control levels by 2 wks following withdrawal from ethanol vapor. These results demonstrate that NMDAR subunit composition can be modulated differentially between adolescents and adults by chronic ethanol exposure and withdrawal. These developmental differences in NMDAR subunits composition may also be associated with the enhanced vulnerability of the adolescent brain to ethanol dependence.

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Section: Discussionmentioning

confidence: 98%

mentioning

confidence: 98%

N-methyl-d-aspartate receptor subunit expression in adult and adolescent brain following chronic ethanol exposure

Pian¹,

Criado²,

Milner³

et al. 2010

Neuroscience

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“…We recently determined the role of NMDA receptors in the development of long-term compensatory neurophysiological changes following adolescent EtOH exposure and found that MK-801 significantly reduced P3 ERP amplitude and increased P3 ERP latency in control, but not in EtOH-exposed rats [14]. These data suggest neuroadaptive changes in NMDA-mediated regulation of the P3 ERP component following adolescent EtOH exposure.…”

Section: Discussionmentioning

confidence: 99%

Effects of adolescent ethanol exposure on event-related oscillations (EROs) in the hippocampus of adult rats

Criado

Ehlers

2010

Behavioural Brain Research

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Electrophysiological studies have shown that adolescent ethanol (EtOH) exposure can produce longterm changes in hippocampal EEG and ERP activity. Recently, evidence has emerged suggesting that event-related oscillations (EROs) may be good indices of alcoholism risk in humans, however, have not been evaluated for their ability to index the effects of EtOH exposure. The objective of the present study was to characterize EROs generated in hippocampus in adult rats exposed to EtOH during adolescence. Adolescent male Sprague-Dawley rats were exposed to EtOH vapor for 12 h/d for 10 days. A time-frequency representation method was used to determine delta, theta, alpha and beta ERO energy and the degree of phase variation in the hippocampus of adult rats exposed to EtOH and age-matched controls. The present results suggest that the decrease in P3 amplitudes, previously observed in adult rats exposed to EtOH during adolescence, is associated with increases in evoked theta ERO energy. These studies suggest that EROs are suitable for characterizing the long-term effects of adolescent EtOH exposure. Further studies are needed to determine the relationship between the mechanisms that regulate these neurophysiological endophenotypes and the consequences of adolescent EtOH exposure.

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“…The mechanism for these effects of alcohol exposure was not identified, but subsequent studies suggested a potential role for changes in NMDA receptor expression and/or function. Rats exposed to ethanol vapor for 12 h/day as juveniles through late adolescence/young adulthood (P24-P60) exhibited significant changes in both cortical and hippocampal EEG following a challenge with the NMDA receptor antagonist MK-801 (Criado et al, 2008). Additionally, expression of NR1 and NR2A subunits in the hippocampus were increased and decreased following 24-hr and 2-week withdrawal, respectively, from alcohol vapor exposure that occurred for 14 h/day starting in the juvenile period (P23-P37) (Pian et al, 2010).…”

Section: Alcohol and Adolescencementioning

confidence: 99%

The effects of abused drugs on adolescent development of corticolimbic circuitry and behavior

Gulley

Juraska

2013

Neuroscience

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Adolescence is a period of significant neurobiological change that occurs as individuals transition from childhood to adulthood. Because the nervous system is in a relatively labile state during this stage of development, it may be especially sensitive to experience-induced plasticity. One such experience that is relatively common to adolescents is the exposure to drugs of abuse, particularly alcohol and psychostimulants. In this review, we highlight recent findings on the long-lasting effects of exposure to these drugs during adolescence in humans as well as in animal models. Whenever possible, our focus is on studies that use comparison groups of adolescent- and adult-exposed subjects as this is a more direct test of the hypothesis that adolescence represents a period of enhanced vulnerability to the effects of drug-induced plasticity. Lastly, we suggest areas of future investigation that are needed and methodological concerns that should be addressed.

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Electrophysiological Effects of Dizocilpine (MK‐801) in Adult Rats Exposed to Ethanol During Adolescence

Cited by 15 publications

References 84 publications

N-methyl-d-aspartate receptor subunit expression in adult and adolescent brain following chronic ethanol exposure

N-methyl-d-aspartate receptor subunit expression in adult and adolescent brain following chronic ethanol exposure

Effects of adolescent ethanol exposure on event-related oscillations (EROs) in the hippocampus of adult rats

The effects of abused drugs on adolescent development of corticolimbic circuitry and behavior

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