Electrophysiological effects of tachykinins and capsaicin on guinea‐pig bronchial parasympathetic ganglion neurones.

Myers, Allen C.; Undem, Bradley J.

doi:10.1113/jphysiol.1993.sp019881

Cited by 104 publications

(86 citation statements)

References 35 publications

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“…This suggests that, in the current in vivo model, HCl-induced sensory nerve stimulation may act on intermediate neurons and parasympathetic neurons where NK 3 receptors play a predominant role [18,19].…”

Section: Discussionmentioning

confidence: 79%

“…Nerve pathways communicating between the oesophagus and airway may also be in the periphery, via autonomic ganglia [18,19]. Anatomical studies have demonstrated the presence of axon collaterals from visceral afferent fibres (gastro-intestinal tract, bladder, airways) in autonomic ganglia [19, 24, 25,].…”

Section: Discussionmentioning

confidence: 99%

“…It has been suggested that tachykinin NK 3 receptors play an important role in parasympathetic ganglia and nerve transmission in the periphery [18][19][20]. Thus, the current authors postulated that the tachykinin NK 3 receptor antagonist SR 142801 [21] might prevent HCl-induced neurogenic inflammation in the airways.…”

mentioning

confidence: 85%

“…This receptor classification has been established from receptorbinding and functional studies using selective agonists or antagonists for tachykinin receptors [16]. It has now been recognised that the expression of the tachykinin NK 3 receptor is confined mainly to the central and peripheral nervous system, whilst tachykinin NK 1 and NK 2 receptors are expressed both in the nervous system and target organs, including airways [17,18].…”

mentioning

confidence: 99%

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Tachykinins and airway microvascular leakage induced by HCl intra-oesophageal instillation

Daoui

D’Agostino²,

Gallelli³

et al. 2002

Eur Respir J

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Gastro-oesophageal reflux is a common clinical disorder associated with a variety of respiratory symptoms, including chronic cough and exacerbation of asthma. In this study, the potential role of acid-induced tachykinin release was examined in guinea pigs and rabbits, by examining the effects of the tachykinin NK1and NK3receptors antagonists (SR 140333 and SR 142801, respectively) (1–10 mg·kg−1) on plasma protein extravasation induced in airways by hydrochloric acid (HCl) infusion in the oesophagus.Guinea pigs were anaesthetised with urethane, while rabbits were subject to neuroleptoanalgesia with hypnorm. Airway vascular leakage was evaluated by measuring extravasation of Evans blue dye. All animals were pretreated with atropine (1 mg·kg−1i.p.), propranolol (1 mg·kg−1i.p.), phosphoramidon (2.5 mg·kg−1i.v.) and saline or tachykinin receptor antagonists (1–10 mg·kg−1i.p.).Infusion of 1 N HCl into the oesophagus led to a three- and five-fold increase in plasma extravasation in the main bronchi and trachea, respectively. This increase was largely prevented by the tachykinin NK1and NK3receptor antagonists SR 140333 and SR 142801 (1–10 mg·kg−1).These results suggest that protein extravasation in the airways, as induced by intra-oesophageal HCl infusion, is mainly dependent on the release of tachykinins, and that both NK1and NK3tachykinin receptors are involved. The results suggest that HCl-induced sensory nerve stimulation may act in the periphery on intermediate neurons and/or ganglia where NK3receptors have been shown to play an important role.

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Section: Discussionmentioning

confidence: 79%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 85%

mentioning

confidence: 99%

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Tachykinins and airway microvascular leakage induced by HCl intra-oesophageal instillation

Daoui

D’Agostino²,

Gallelli³

et al. 2002

Eur Respir J

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“…However, contraction of the small-and medium-sized human bronchi can also be mediated by tachykinin NK 1 receptors [10,11]. Studies on guinea pig and human airways show that NK 3 receptors facilitate cholinergic neurotransmission [12][13][14][15]. Therefore, agents blocking all three receptors may be useful in the treatment of asthma.…”

Section: Introductionmentioning

confidence: 99%

The triple neurokinin-receptor antagonist CS-003 inhibits neurokinin A-induced bronchoconstriction in patients with asthma

Schelfhout

Louis

Lenz

et al. 2006

Pulmonary Pharmacology & Therapeutics

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Abstract:Neurokinin A (NKA) causes bronchoconstriction in asthmatic patients. In vitro both NK 1 and NK 2 receptors can mediate airway contraction. Moreover in guinea pigs, NK 3 receptors facilitate cholinergic neurotransmission. Dual tachykinin NK 1 /NK 2 receptor antagonism results in prevention of NKA-induced bronchoconstriction. We have now examined the effect of a single dose of the triple tachykinin receptor antagonist CS-003 on NKAinduced bronchoconstriction in asthmatics.A double blind, crossover, placebo-controlled trial in 16 mild asthmatics was performed. One single dose of CS-003 (200 mg, solution in distilled water) or matched placebo was given orally on the assessment days. NKAprovocation tests were performed pre-dose and 1,8 and 24 h after dosing.There was a significant shift to the right of the dose-response curve at 1 and 8 h after intake of CS-003. PC 20 was not reached in 12/16 patients at 1 h post-dose and in 5/16 patients at 8h post-dose. This did not occur under placebo treatment.A single dose of 200 mg CS-003 protected significantly against NKA-induced bronchoconstriction at 1 and 8 h post-dose in mild asthmatics.

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Anatomical characteristics of tonic and phasic postganglionic neurons in guinea pig bronchial parasympathetic ganglia

Myers

2000

J. Comp. Neurol.

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Anatomical characteristics of principal parasympathetic ganglia neurons on the guinea pig primary bronchus were analyzed, and the procedure for localizing the ganglia without the aid of staining for in vitro physiological studies is described. The neurons were tightly packed within a perineural sheath, and the cell bodies formed a homogeneous population based on size and shape. By using intracellular electrophysiological recordings, unstained neurons within these ganglia were characterized with suprathreshold depolarizing stimuli as having either accommodating action potential patterns (phasic neurons) or repetitive action potential patterns (tonic neurons). After determining whether a cell was tonic or phasic, it was injected with either horseradish peroxidase or Neurobiotin for characterization of its dendrites. There were no differences between tonic and phasic neurons, and both exhibited the following: (1) dendrites were multiple and branching; (2) all processes (axon and dendrites) arose from a circumscribed area on the somatic surface; (3) the initial direction of the processes was usually toward the center of the ganglion, creating a very dense intraganglionic neuropil; (4) tapering processes (presumed dendrites) extended beyond the border of the perineural sheath; and (5) many processes terminated with bouton‐like swellings near the somatic surfaces of neighboring neurons within the same ganglion. Electron microscopic examination of dendritic and cell body membranes revealed that greater than 90% of the synapses occurred on dendrites. Based on immunohistochemical staining, all neurons were calbindin negative. These results indicate a relatively homogeneous population of neurons in bronchial parasympathetic ganglia displaying dendritic characteristics compatible with complex integrative properties. J. Comp. Neurol. 419:439–450, 2000. © 2000 Wiley‐Liss, Inc.

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Electrophysiological effects of tachykinins and capsaicin on guinea‐pig bronchial parasympathetic ganglion neurones.

Cited by 104 publications

References 35 publications

Tachykinins and airway microvascular leakage induced by HCl intra-oesophageal instillation

Tachykinins and airway microvascular leakage induced by HCl intra-oesophageal instillation

The triple neurokinin-receptor antagonist CS-003 inhibits neurokinin A-induced bronchoconstriction in patients with asthma

Anatomical characteristics of tonic and phasic postganglionic neurons in guinea pig bronchial parasympathetic ganglia

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