Electrophysiological evidence of ipsilateral reno–renal reflexes in the cat

Genovesi, Simonetta; Pieruzzi, Federico; Centonza, Leonardo; Wijnmaalen, Paulien; Zanchetti, Alberto; Stella, Andréa

doi:10.1016/s0165-1838(97)00033-7

Cited by 3 publications

(2 citation statements)

References 20 publications

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“…The reno-renal reflex has been studied most intensively in rats [68], but has also been demonstrated in cats [69,70] and dogs [71]. To our knowledge, there has only been one study performed in pigs, which concluded that pelvic distension and the hyperperfusion of one kidney showed no evidence for a reno-renal reflex, considering diuresis of the contralateral organ as an outcome parameter [72].…”

Section: Discussionmentioning

confidence: 99%

Effect of Low-Frequency Renal Nerve Stimulation on Renal Glucose Release during Normoglycemia and a Hypoglycemic Clamp in Pigs

Nistor,

Schmidt,

Klingner

et al. 2024

IJMS

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Previously, we demonstrated that renal denervation in pigs reduces renal glucose release during a hypoglycemic episode. In this study we set out to examine changes in side-dependent renal net glucose release (SGN) through unilateral low-frequency stimulation (LFS) of the renal plexus with a pulse generator (2–5 Hz) during normoglycemia (60 min) and insulin-induced hypoglycemia ≤3.5 mmol/L (75 min) in seven pigs. The jugular vein, carotid artery, renal artery and vein, and both ureters were catheterized for measurement purposes, blood pressure management, and drug and fluid infusions. Para-aminohippurate (PAH) and inulin infusions were used to determine side-dependent renal plasma flow (SRP) and glomerular filtration rate (GFR). In a linear mixed model, LFS caused no change in SRP but decreased sodium excretion (p < 0.0001), as well as decreasing GFR during hypoglycemia (p = 0.0176). In a linear mixed model, only hypoglycemic conditions exerted significant effects on SGN (p = 0.001), whereas LFS did not. In a Wilcoxon signed rank exact test, LFS significantly increased SGN (p = 0.03125) and decreased sodium excretion (p = 0.0017) and urinary flow rate (p = 0.0129) when only considering the first instance LFS followed a preceding period of non-stimulation during normoglycemia. To conclude, this study represents, to our knowledge, the first description of an induction of renal gluconeogenesis by LFS.

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Section: Discussionmentioning

confidence: 99%

Effect of Low-Frequency Renal Nerve Stimulation on Renal Glucose Release during Normoglycemia and a Hypoglycemic Clamp in Pigs

Nistor,

Schmidt,

Klingner

et al. 2024

IJMS

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“…The backflow of concentrated urine or occlusion of the renal artery or ureter increased ipsilateral RSNA in rats (18,21), whereas renal venous occlusion decreased the RSNA in rats and dogs (12,25). Renal denervation increased the ipsilateral RSNA in cats (8). Why the similar kind of renal intervention caused the variant responses in the ipsilateral RSNA remains unexplained, although species difference cannot be neglected.…”

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confidence: 99%

Partial renal ischemia elicits heterogeneous control of renal sympathetic nerve activity to ischemic and nonischemic regions of the kidney

Shimizu¹,

Matsukawa²,

Murata³

et al. 2006

American Journal of Physiology-Regulatory, Integrative and Comp

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We tested the hypothesis that renal sympathetic nerve activity (RSNA) to the ischemic and nonischemic regions responded differently during partial ischemia of the kidney in pentobarbital-anesthetized cats. The renal artery divides into two branches at the front of the renal hilus: one branch perfuses predominantly the dorsal half of the kidney, and the other perfuses its ventral half. We identified the innervated area of a renal nerve bundle by supramaximal electrical stimulation and subsequently determined the changes in RSNA in response to occlusion of either renal arterial branch for 3 min. RSNA to the nonischemic region of the kidney gradually decreased by 23 +/- 4% during partial renal ischemia, whereas RSNA to the ischemic region of the same kidney showed no significant change. Crushing either all renal nerve bundles or only the renal nerve bundles terminated to the ischemic region abolished the decrease in RSNA to the nonischemic region. Furthermore, intra-arterial administration of a prostaglandin synthesis inhibitor (meclofenamate, 4 mg/kg) abolished the decrease in RSNA to the nonischemic region of the kidney. Following spinal transection at the level of T7, the inhibitory response in RSNA to the nonischemic region disappeared, whereas the RSNA to the ischemic region was markedly augmented by 47 +/- 17%. Thus it is likely that renal chemoreceptors activated during renal partial ischemia elicit heterogeneous control of renal sympathetic outflows to the ischemic and nonischemic regions of the same kidney, which may be determined by a net output between the supraspinal inhibitory and spinal excitatory reflexes.

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Effects of a reversible ‘nephrectomy’ on renal sympathetic activity and blood pressure in the rat

Recordati¹,

Zorzoli²,

Zanchetti³

2000

Journal of Hypertension

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The decrease in RSNA observed in rats during bilateral nephrectomy, in contrast to the increase observed in rats with one or both kidneys intact, suggests that the kidney as a whole exerts a supportive role on sympathetic nerve activity. The hypertension and tachycardia that follows the reopening of the right kidney hilum appears to be caused by the generation of endogenous angiotensin II; this is the first evidence of an acute angiotensin-mediated renal hypertension.

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Electrophysiological evidence of ipsilateral reno–renal reflexes in the cat

Cited by 3 publications

References 20 publications

Effect of Low-Frequency Renal Nerve Stimulation on Renal Glucose Release during Normoglycemia and a Hypoglycemic Clamp in Pigs

Effect of Low-Frequency Renal Nerve Stimulation on Renal Glucose Release during Normoglycemia and a Hypoglycemic Clamp in Pigs

Partial renal ischemia elicits heterogeneous control of renal sympathetic nerve activity to ischemic and nonischemic regions of the kidney

Effects of a reversible ‘nephrectomy’ on renal sympathetic activity and blood pressure in the rat

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