Electrophysiological investigation of the contribution of attention to altered pain inhibition processes in patients with irritable bowel syndrome

Rustamov, Nabi; Wagenaar-Tison, Alice; Doyer, Elysa; Piché, Mathieu

doi:10.1186/s12576-020-00774-x

Cited by 9 publications

(9 citation statements)

References 96 publications

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“…A source localization of power change was performed to estimate the cortical sources associated with pain relief (see Refs. 58 and 59 for a source estimation pipeline). The power decomposition on the source from 4 to 7 Hz was computed using Welch method.…”

Section: Methodsmentioning

confidence: 99%

Relief of chronic pain associated with increase in midline frontal theta power

Rustamov

Wilson

Fogarty

et al. 2022

PR9

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Introduction: There is a need to identify objective cortical electrophysiological correlates for pain relief that could potentially contribute to a better pain management. However, the field of developing brain biomarkers for pain relief is still largely underexplored. Objectives: The objective of this study was to investigate cortical electrophysiological correlates associated with relief from chronic pain. Those features of pain relief could serve as potential targets for novel therapeutic interventions to treat pain. Methods: In 12 patients with chronic pain in the upper or lower extremity undergoing a clinically indicated nerve block procedure, brain activity was recorded by means of electroencephalogram before and 30 minutes after the nerve block procedure. To determine the specific cortical electrophysiological correlates of relief from chronic pain, 12 healthy participants undergoing cold-pressor test to induce experimental acute pain were used as a control group. The data were analyzed to characterize power spectral density patterns of pain relief and identify their source generators at cortical level. Results: Chronic pain relief was associated with significant delta, theta, and alpha power increase at the frontal area. However, only midfrontal theta power increase showed significant positive correlation with magnitude of reduction in pain intensity. The sources of theta power rebound were located in the left dorsolateral prefrontal cortex (DLPFC) and midline frontal cortex. Furthermore, theta power increase in the midline frontal cortex was significantly higher with chronic vs acute pain relief. Conclusion: These findings may provide basis for targeting chronic pain relief via modulation of the midline frontal theta oscillations.

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Section: Methodsmentioning

confidence: 99%

Relief of chronic pain associated with increase in midline frontal theta power

Rustamov

Wilson

Fogarty

et al. 2022

PR9

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“…The total number of participants evaluated in the reviewed studies is 255,068, these being 18 participants from the smallest sample (Rustamov et al, 2020 ) and 161,490 participants from the largest (Chen et al, 2016 ). The proportion of female (51%) and male (49%) participants is balanced, and the mean age is 40.5 years (SD = 7.9), with a range between 18 and 85 years of age.…”

Section: Resultsmentioning

confidence: 99%

“…Lam et al (2019) and Wong et al (2019b) state that one of the principal explanations for the demonstrated biases in the attention network is the presence of chronic thoracic, abdominal and/or pelvic pain, anxiety related to the symptoms, hypervigilance of the pain and visceral hypersensitivity. Along the same lines, another possible explanation for the attention bias is the proposal made by Rustamov et al (2020), which suggests that persons with chronic pain direct a great part of their attention resources to information related to the pain due to their inability to inhibit it.…”

Section: Discussionmentioning

confidence: 99%

Psychopathological and neuropsychological disorders associated with chronic primary visceral pain: Systematic review

Arévalo-Martínez

Manso²,

García-Baamonde³

et al. 2022

Front. Psychol.

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The World Health Organization (WHO), in its last review of its International Classification of Diseases, established a new classification for chronic pain. Among the principal categories, of particular interest is chronic primary pain as a new type of diagnosis in those cases in which the etiology of the disease is not clear, being termed as chronic primary visceral pain when it is situated in the thorax, abdomen, or pelvis. Due to the novelty of the term, the objective of the systematic review was to examine the psychopathological and neuropsychological disorders associated with chronic primary visceral pain. We carried out a search of the scientific literature following the PRISMA directives using the Pubmed, Medline, PsycInfo and Scopus databases. A total of 33 articles were selected after applying the inclusion and exclusion criteria. The analysis of the studies showed that most persons with chronic primary visceral pain suffer from at least one psychological disorder; the most prevalent being anxiety, depressive or somatoform disorders. The most frequent psychopathological symptoms are anxiety, depression and somatization. Similarly, the findings are insufficient to determine the existence of deficits in the domains of executive functioning, memory and intelligence. However, the existence of attention biases does seem to be clear. This review supposes a starting point for conceptualizing chronic primary visceral pain. It is necessary to continue further research so as to obtain a better understanding of this pathology and the disorders associated.

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“…A Morlet wavelet convolution was computed using the channel time–frequency option. 81 , 82 Thirty-five linearly spaced frequencies were computed between 65 and 100 Hz. For each patient, time–frequency data were averaged across all epochs per condition.…”

Section: Methodsmentioning

confidence: 99%

Theta–gamma coupling as a cortical biomarker of brain–computer interface-mediated motor recovery in chronic stroke

Rustamov

Humphries

Carter

et al. 2022

Brain Communications

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Chronic stroke patients with upper limb motor disabilities are now beginning to see treatment options that were not previously available. To date, the two options recently approved by the United States Food and Drug Administration include vagus nerve stimulation and brain-computer interface therapy. While the mechanisms for vagus nerve stimulation have been well defined, the mechanisms underlying brain-computer interface-driven motor rehabilitation are largely unknown. Given that cross-frequency coupling has been associated with a wide variety of higher-order functions involved in learning and memory, we hypothesized this rhythm specific mechanism would correlate with the functional improvements effected by a brain-computer interface. This study investigated whether the motor improvements in chronic stroke patients induced with a brain-computer interface therapy is associated with alterations in phase-amplitude coupling, a type of cross-frequency coupling. Seventeen chronic hemiparetic stroke patients used a robotic hand orthosis controlled with contralesional motor cortical signals measured with EEG. Patients regularly performed a therapeutic brain-computer interface task for 12 weeks. Resting state EEG recordings and motor function data were acquired before initiating brain-computer interface therapy and once every four weeks after the therapy. Changes in phase-amplitude coupling values were assessed and correlated with motor function improvements. To establish whether coupling between two different frequency bands was more functionally important than either of those rhythms alone, we calculated power spectra as well. We found that theta-gamma coupling was enhanced bilaterally at the motor areas and showed significant correlations across brain-computer interface therapy sessions. Importantly, increase in theta-gamma coupling positively correlated with motor recovery over the course of rehabilitation. The sources of theta-gamma coupling increase following brain-computer interface therapy were mostly located in the hand regions of primary motor cortex on the left and right cerebral hemispheres. Beta-gamma coupling decreased bilaterally at the frontal areas following the therapy, but these effects did not correlate with motor recovery. Alpha-gamma coupling was not altered by brain-computer interface therapy. Power spectra did not change significantly over the course of the brain-computer interface therapy. The significant functional improvement in chronic stroke patients induced by brain-computer interface therapy was strongly correlated with increased theta-gamma coupling in bihemispheric motor regions. These findings support the notion that specific cross frequency coupling dynamics in the brain likely play a mechanistic role in mediating motor recovery in the chronic phase of stroke recovery.

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Electrophysiological investigation of the contribution of attention to altered pain inhibition processes in patients with irritable bowel syndrome

Cited by 9 publications

References 96 publications

Relief of chronic pain associated with increase in midline frontal theta power

Relief of chronic pain associated with increase in midline frontal theta power

Psychopathological and neuropsychological disorders associated with chronic primary visceral pain: Systematic review

Theta–gamma coupling as a cortical biomarker of brain–computer interface-mediated motor recovery in chronic stroke

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