Electrophysiological parameters as biomarkers for psychiatry: Intra-individual variability and influencing factors

Sarlon, Jan; Plaszczyk, Simone; Engel, Sinah; Oertel-Knöchel, Viola

doi:10.1016/j.ijpsycho.2017.11.011

Cited by 6 publications

(4 citation statements)

References 71 publications

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“…As the larger study from which these data arose additionally assessed electroencephalography, right-handedness was required as per convention to minimize potential differences in cortical lateralization (Kelly et al, 2015). They were also to refrain from exercising, drinking caffeine, and eating 2 hr prior to their laboratory session and abstain from alcohol 24 hr prior, as these factors influence HRV (Sarlon et al, 2018). Weight-Focused Restraint (e.g., attempts to eat less to control weight or shape).…”

Section: Methods Participantsmentioning

confidence: 99%

Disinhibited or Disconnected? Dietary Restraint Attenuates the Relationship Between Heart Rate Variability and Stress-Induced Suppression of Food Intake

McGeown,

Mushquash,

De Young

2024

Journal of Psychophysiology

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Literature on restrained eaters posits that the capacity to successfully diet is cognitively demanding, requiring exertion of cognitive control over one’s eating behaviour. Demands that deplete this limited inner resource can thus lead restrained eaters to become disinhibited and consume large amounts of food. Although self-regulation is inferred to play a role, it has not yet been studied in combination with its physiological correlates. As low heart rate variability (HRV) is associated with lower self-regulatory capacity, and acute mental stressors decrease HRV, it was hypothesized that reduced HRV during stress may mediate the relationship between stress and food intake, and that the mediation may be moderated by dietary restraint. Specifically, the moderation hypothesis predicted more restrained eaters would exhibit a stronger relationship between low HRV and intake. Female undergraduates ( n = 92) were randomized to a stress or control condition while HRV was recorded. Participants subsequently engaged in a bogus taste test to quantify post-stress consumption. Restraint was conceptualized using Hagan and colleagues’ (2017) latent restraint factors. A significant moderated mediation emerged for Weight-Focused Restraint, ab3 = .196, SE = .077, 95% CI [.060, .361] and Calorie Counting, ab3 = .062, SE = .023, 95% CI [.024, .115]. However, contrary to expectation, stress-induced HRV reduction was associated with decreased intake for those low in restraint, whereas intake was unrelated to HRV for individuals with higher dietary restraint. Further, there was no evidence of traditionally-defined disinhibition in more restrained eaters. Results suggest those with higher restraint show a relative disconnection from internal physiological cues shown to affect intake under stress in less restrained individuals.

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Section: Methods Participantsmentioning

confidence: 99%

Disinhibited or Disconnected? Dietary Restraint Attenuates the Relationship Between Heart Rate Variability and Stress-Induced Suppression of Food Intake

McGeown,

Mushquash,

De Young

2024

Journal of Psychophysiology

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“…Study appointments take place at the same time of the day for both admission and discharge to eliminate the influence of circadian rhythm on HRV. 56 HRV measurement will be performed according to GRAPH 54 by experienced sport scientists. All study appointments will be integrated into the clinic schedule to ensure a smooth process.…”

Section: Methodsmentioning

confidence: 99%

Heart rate vARiability and physical activity in inpatient treatMent of burnOut and DepressIon (HARMODI): protocol of a cross-sectional study with up to 8-week follow up

Turner,

Brühl,

Böker

et al. 2024

BMJ Open

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IntroductionChronic stress can cause an imbalance within the autonomic nervous system, thereby affecting cardiovascular and mental health. Physical activity (PA) may have a positive effect on the autonomic nervous system and stress-related disorders, such as depression and burnout. Heart rate variability (HRV) is a non-invasive marker of the autonomic nervous system. However, limited and inconsistent data exist on the exact relationship between HRV, PA and depression and burnout symptoms. The HARMODI study aims to explore whether HRV is a feasible marker of depression and burnout symptoms and aims to evaluate the role of PA in the treatment of stress-related disorders.Methods and analysesThis is an observational study with a cross-sectional up to 8 week follow-up study design. A total of 153 patients, undergoing psychiatric inpatient treatment with burnout syndrome (Z73) and depressive episode (F32 or F33) or adjustment disorder (F43.2), will be recruited. Data on depression and burnout symptoms, HRV recordings (24-hour, supine, standing and exercise stress test), cognitive function, cardiorespiratory fitness, cardiovascular health, balance and strength will be collected at baseline (T1) and after up to 8 weeks (T2). Continuous data on PA and Ecological Momentary Assessments of exhaustion, mood and tension will be monitored daily throughout inpatient treatment. Multiple regression models, adjusted for potential confounders, will assess the association between HRV as the primary outcome, PA and depression and burnout severity score.Ethics and disseminationThe protocol has been approved by Swiss Ethics Committee, Cantonal Ethics Committee Zürich. Results of HARMODI will be disseminated through peer-reviewed journals and conference presentations.Trial registration numberNCT05874856.

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“…Despite the rising popularity of HRV measurements in the assessment of stress, there are rising concerns regarding high levels of within-subjects variability in HRV measurements ( Uhlig et al, 2020 ), a variety of HRV measurement protocols ( Vila et al, 2019 ), as well as poorer reliability in real-world recordings ( von Rosenberg et al, 2017 ) and in clinical populations ( Sandercock et al, 2005 ) compared to lab-based scenarios or healthy populations. Some authors suggest the use of broader analyzing tools instead of HRV only ( Schumann et al, 2017 ; Sarlon et al, 2018 ).…”

Section: Introductionmentioning

confidence: 99%

Electrophysiological correlates of mindfulness in patients with major depressive disorder

Sarlon

Brühl²,

Lang³

et al. 2022

Front. Neurosci.

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ObjectivesMindfulness-based interventions (MBI) can reduce both stress and depressive symptoms. However, the impact of mindfulness on stress level in depressed subjects remains unclear. This study aims to assess electrophysiological correlates of mindfulness in patients with major depressive disorder (MDD) at baseline, under stress exposure, and in relaxation following stress exposure.MethodsPerceived mindfulness was assessed with the Freiburger Mindfulness Inventory (FMI) in 89 inpatients (mean age 51) with MDD [mean Beck Depression Inventory (BDI) 30]. Electrophysiological parameters [resting heart rate (RHR), heart rate variability (HRV), respiration rate, skin conductance, and skin temperature] were recorded at 5-min baseline, 1-min stress exposure, and 5-min self-induced relaxation.ResultsFreiburger Mindfulness Inventory was strongly inversely correlated with symptom severity measured by BDI (r = –0.53, p < 0.001). No correlations between FM score and electrophysiological parameters in any of the three conditions (baseline, stress exposure, relaxed state) could be found. The factor openness was associated with higher VLF (very low frequency of HRV) in the baseline condition. However, this correlation was no more significant after regression analysis when corrected for respiratory rate, age, and sex.ConclusionAutonomous nervous reactivity in depression was not associated with perceived mindfulness as measured by FMI score and presented electrophysiological parameters, despite the strong inverse correlation between state mindfulness and symptom severity.

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Electrophysiological parameters as biomarkers for psychiatry: Intra-individual variability and influencing factors

Cited by 6 publications

References 71 publications

Disinhibited or Disconnected? Dietary Restraint Attenuates the Relationship Between Heart Rate Variability and Stress-Induced Suppression of Food Intake

Disinhibited or Disconnected? Dietary Restraint Attenuates the Relationship Between Heart Rate Variability and Stress-Induced Suppression of Food Intake

Heart rate vARiability and physical activity in inpatient treatMent of burnOut and DepressIon (HARMODI): protocol of a cross-sectional study with up to 8-week follow up

Electrophysiological correlates of mindfulness in patients with major depressive disorder

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