Electrophysiological Patterning of the Heart

Boukens, Bastiaan J.; Christoffels, Vincent M.

doi:10.1007/s00246-012-0237-4

Cited by 14 publications

(13 citation statements)

References 69 publications

(48 reference statements)

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“…Several T-box and Iroquois homeobox transcription factors, which regulate cardiac development, have been shown to pattern areas of ion channel expression throughout the heart and parts of the conduction system (Boukens & Christoffels, 2012; Zhang et al, 2011; Gaborit et al, 2012; Bakker et al, 2008; Oyamada et al, 2013; Wiese et al, 2009). A central component of the cardiac conduction system is the sinoatrial node (SAN), which functions as the pacemaker to set the heartbeat.…”

Section: Multilayered Regulation Of Cx43 Biogenesismentioning

confidence: 99%

“…The ventricular conduction system is extensively coupled via GJs containing specific combinations and region-specific patterns of mostly Cx40 and Cx43 (Oyamada et al, 2013; Boukens & Christoffels, 2012; van Veen et al, 2001). Irx3 antithetically regulates Cx40 and Cx43 whereby Irx3 indirectly activates Cx40 expression but directly represses Cx43 transcription.…”

Section: Multilayered Regulation Of Cx43 Biogenesismentioning

confidence: 99%

“…Throughout the heart, GJs are made up of specific combinations of the following Cxs: Cx40, Cx43, Cx45, and Cx30.2, of which Cx43 is the most abundantly expressed in ventricular muscle (Zhang & Shaw, 2013; Boukens & Christoffels, 2012; Oyamada et al, 2013). In individual ventricular cardiomyocytes, Cx43 is localized in large aggregates at longitudinal ends of the cell, along with cadherins, desmosomes, and other ion channels (Delmar, 2004; Severs, 1989; Forbes & Sperelakis, 1985; Palatinus et al, 2012).…”

Section: Introductionmentioning

confidence: 99%

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Trafficking Highways to the Intercalated Disc: New Insights Unlocking the Specificity of Connexin 43 Localization

Zhang

Shaw

2014

Cell Communication & Adhesion

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With each heartbeat, billions of cardiomyocytes work in concert to propagate the electrical excitation needed to effectively circulate blood. Regulated expression and timely delivery of connexin proteins to form gap junctions at the specialized cell – cell contact region, known as the intercalated disc, is essential to ventricular cardiomyocyte coupling. We focus this review on several regulatory mechanisms that have been recently found to govern the lifecycle of connexin 43 (Cx43), the short-lived and most abundantly expressed connexin in cardiac ventricular muscle. The Cx43 lifecycle begins with gene expression, followed by oligomerization into hexameric channels, and then cytoskeletal-based transport toward the disc region. Once delivered, hemichannels interact with resident disc proteins and are organized to effect intercellular coupling. We highlight recent studies exploring regulation of Cx43 localization to the intercalated disc, with emphasis on alternatively translated Cx43 isoforms and cytoskeletal transport machinery that together regulate Cx43 gap junction coupling between cardiomyocytes.

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Section: Multilayered Regulation Of Cx43 Biogenesismentioning

confidence: 99%

Section: Multilayered Regulation Of Cx43 Biogenesismentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Trafficking Highways to the Intercalated Disc: New Insights Unlocking the Specificity of Connexin 43 Localization

Zhang

Shaw

2014

Cell Communication & Adhesion

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“…The lack of significant changes in the excitation sequence of the VE, in dispersion of ARIs times and the termination of repolarization, possibly is due to heterogeneous change in the action potential duration of cardiomyocytes in different epicardial areas. According to the contemporary paradigm, (16)(17)(18) the electrical and mechanical inhomogeneity of the myocardium is a modulator performing fine adjustments to the factors of the internal and external environments of the organism; that is, it performs an adaptive function.…”

Section: Discussionmentioning

confidence: 99%

Electrical and Contractile Properties of the Heart Ventricle in Response to Ambient Temperature Changes in Frog Rana temporaria

Kibler¹,

Nuzhny²,

Prosheva³

2017

IJBM

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The aim of the study was to investigate the dynamics of change in the intraventricular pressure, depolarization and repolarization processes on the ventricular epicardium (VE) in Rana temporaria in response to a rise in ambient temperature. By methods of catheterization and electrophysiological mapping the dynamics of the intraventricular pressure change, the processes of depolarization and repolarization on the epicardium of the heart ventricle in adult frogs in a temperature range from 10°C to 20°C were studied. We found that the rise in body temperature by 10°C led to increase of the maximal systolic ventricular pressure (MSVP), maximal value of the MSVP derivative and maximal rate of MSVP decline but to a decrease in dispersion of depolarization time and durations of activation-recovery intervals on the ventral and dorsal sides of VE. The role of the electrical inhomogeneity of the myocardium was shown to be a modulator performing fine adjustment to factors in the external environment of the organism.

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“…These include endothelin-1 (Et1) and neuregulin 1 (Nrg1), both of which have been implicated as potential inducers of fast conduction (Gourdie et al, 1998;Hall et al, 2004;Milan et al, 2006;Patel and Kos, 2005;Rentschler et al, 2002;Sedmera et al, 2008;Takebayashi-Suzuki et al, 2000). Conversely, Bmp2 is highly expressed by the AVJ and is thought to be a negative regulator of Cx40 and Nav1.5 expression through its downstream targets Tbx2 and Tbx3 (Christoffels et al, 2004b;Hoogaars et al, 2004;Singh et al, 2012;Yamada et al, 2000;Boukens and Christoffels, 2012;van den Boogaard et al, 2012).…”

Section: Avj Myocytes Differentiate With Physiological Features Uniqumentioning

confidence: 99%

Reciprocal myocardial-endocardial interactions pattern the delay in atrioventricular junction conduction

et al. 2014

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Efficient blood flow depends on two developmental processes that occur within the atrioventricular junction (AVJ) of the heart: conduction delay, which entrains sequential chamber contraction; and valve formation, which prevents retrograde fluid movement. Defects in either result in severe congenital heart disease; however, little is known about the interplay between these two crucial developmental processes. Here, we show that AVJ conduction delay is locally assigned by the morphogenetic events that initiate valve formation. Our data demonstrate that physical separation from endocardial-derived factors prevents AVJ myocardium from becoming fast conducting. Mechanistically, this physical separation is induced by myocardial-derived factors that support cardiac jelly deposition at the onset of valve formation. These data offer a novel paradigm for conduction patterning, whereby reciprocal myocardialendocardial interactions coordinate the processes of valve formation with establishment of conduction delay. This, in turn, synchronizes the electrophysiological and structural events necessary for the optimization of blood flow through the developing heart.

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Electrophysiological Patterning of the Heart

Cited by 14 publications

References 69 publications

Trafficking Highways to the Intercalated Disc: New Insights Unlocking the Specificity of Connexin 43 Localization

Trafficking Highways to the Intercalated Disc: New Insights Unlocking the Specificity of Connexin 43 Localization

Electrical and Contractile Properties of the Heart Ventricle in Response to Ambient Temperature Changes in Frog Rana temporaria

Reciprocal myocardial-endocardial interactions pattern the delay in atrioventricular junction conduction

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