Electrophysiological properties of ventral cochlear nucleus neurons of the dog

Bal, Ramazan; Baydaş, Gıyasettin; Nazıroğlu, Mustafa

doi:10.1016/j.heares.2009.07.004

Cited by 17 publications

(6 citation statements)

References 72 publications

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“…However, slice recordings revealed longer AP duration in BCs compared to SCs (cat: Bal and Baydas, 2009; dog: Bal et al, 2009; mouse: Yang et al, 2016). To test whether the APs differ between fairly immature BCs and SCs, current clamp recordings were conducted in acute slices from P10–18 mice.…”

Section: Resultsmentioning

confidence: 95%

Functional Development of Principal Neurons in the Anteroventral Cochlear Nucleus Extends Beyond Hearing Onset

Müller

Jovanovic

Keine

et al. 2019

Front. Cell. Neurosci.

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Sound information is transduced into graded receptor potential by cochlear hair cells and encoded as discrete action potentials of auditory nerve fibers. In the cochlear nucleus, auditory nerve fibers convey this information through morphologically distinct synaptic terminals onto bushy cells (BCs) and stellate cells (SCs) for processing of different sound features. With expanding use of transgenic mouse models, it is increasingly important to understand the in vivo functional development of these neurons in mice. We characterized the maturation of spontaneous and acoustically evoked activity in BCs and SCs by acquiring single-unit juxtacellular recordings between hearing onset (P12) and young adulthood (P30) of anesthetized CBA/J mice. In both cell types, hearing sensitivity and characteristic frequency (CF) range are mostly adult-like by P14, consistent with rapid maturation of the auditory periphery. In BCs, however, some physiological features like maximal firing rate, dynamic range, temporal response properties, recovery from post-stimulus depression, first spike latency (FSL) and encoding of sinusoid amplitude modulation undergo further maturation up to P18. In SCs, the development of excitatory responses is even more prolonged, indicated by a gradual increase in spontaneous and maximum firing rates up to P30. In the same cell type, broadly tuned acoustically evoked inhibition is immediately effective at hearing onset, covering the low- and high-frequency flanks of the excitatory response area. Together, these data suggest that maturation of auditory processing in the parallel ascending BC and SC streams engages distinct mechanisms at the first central synapses that may differently depend on the early auditory experience.

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Section: Resultsmentioning

confidence: 95%

Functional Development of Principal Neurons in the Anteroventral Cochlear Nucleus Extends Beyond Hearing Onset

Müller

Jovanovic

Keine

et al. 2019

Front. Cell. Neurosci.

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“…It is not known how individual octopus cells cope with the long traveling wave delays, whether their inputs span a larger range of delays, or whether there is a systematic difference in latency to firing across the population of octopus cells. The biophysical properties of these cells have not been examined in mature animals but in puppies and kittens they are much like those in mice except that they have higher input resistances (Bal et al, 2009; Bal and Baydas, 2009). Our results show that increasing the input resistance of octopus cells increases the delay range to which they are most sensitive (Fig.…”

Section: Discussionmentioning

confidence: 99%

Generating Synchrony from the Asynchronous: Compensation for Cochlear Traveling Wave Delays by the Dendrites of Individual Brainstem Neurons

McGinley¹,

Liberman²,

Bal³

et al. 2012

Journal of Neuroscience

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Broadband transient sounds, such as clicks and consonants, activate a traveling wave in the cochlea. This wave evokes firing in auditory nerve fibers that are tuned to high frequencies several milliseconds earlier than in fibers tuned to low frequencies. Despite this substantial traveling wave delay, octopus cells in the brainstem receive broadband input and respond to clicks with submillisecond temporal precision. The dendrites of octopus cells lie perpendicular to the tonotopically organized array of auditory nerve fibers, placing the earliest arriving inputs most distally and the latest arriving closest to the soma. Here, we test the hypothesis that the topographic arrangement of synaptic inputs on dendrites of octopus cells allows octopus cells to compensate the traveling wave delay. We show that in mice the full cochlear traveling wave delay is 1.6 ms. Because the dendrites of each octopus cell spread across about one third of the tonotopic axis, a click evokes a soma directed sweep of synaptic input lasting 0.5 ms in individual octopus cells. Morphologically and biophysically realistic, computational models of octopus cells show that soma-directed sweeps with durations matching in vivo measurements result in the largest and sharpest somatic excitatory postsynaptic potentials (EPSPs). A low input resistance and activation of a low-voltage-activated potassium conductance that are characteristic of octopus cells are important determinants of sweep sensitivity. We conclude that octopus cells have dendritic morphologies and biophysics tailored to accomplish the precise encoding of broadband transient sounds.

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“…Temporal coding in the ventral cochlear nucleus is very similar among different mammals (e.g., dogs [74], monkeys [75]), but not all mammals show refined ITD tuning in the MSO. Behavioral assessment shows that rats are unlikely to use ITDs [76*], in line with the poorly developed structure of their MSO [29].…”

Section: Discussionmentioning

confidence: 99%

Sound localization: Jeffress and beyond

Ashida

Carr

2011

Current Opinion in Neurobiology

139

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Many animals use the interaural time differences (ITDs) to locate the source of low frequency sounds. The place coding theory proposed by Jeffress has long been a dominant model to account for the neural mechanisms of ITD detection. Recent research, however, suggests a wider range of strategies for ITD coding in the binaural auditory brainstem. We discuss how ITD is coded in avian, mammalian, and reptilian nervous systems, and review underlying synaptic and cellular properties that enable precise temporal computation. The latest advances in recording and analysis techniques provide powerful tools for both overcoming and utilizing the large field potentials in these nuclei.

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Electrophysiological properties of ventral cochlear nucleus neurons of the dog

Cited by 17 publications

References 72 publications

Functional Development of Principal Neurons in the Anteroventral Cochlear Nucleus Extends Beyond Hearing Onset

Functional Development of Principal Neurons in the Anteroventral Cochlear Nucleus Extends Beyond Hearing Onset

Generating Synchrony from the Asynchronous: Compensation for Cochlear Traveling Wave Delays by the Dendrites of Individual Brainstem Neurons

Sound localization: Jeffress and beyond

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