Electrophysiological Responses to Oxytocin and ATP in Monolayers of a Human Sweat Gland Cell Line

Ring, Avi; Mörk, Ann‐Christin

doi:10.1006/bbrc.1997.9995

Cited by 17 publications

(9 citation statements)

References 18 publications

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“…These results suggested that, similar to the intact sweat gland and other exocrine cells, K + and Cl − effluxes occurred through Ca 2+ ‐activated channels. Calcium‐activated chloride effluxes from the NCL‐SG3 cells were later confirmed as was the presence and functionality of a calcium‐activated chloride channel (CaCC) TMEM16A …”

Section: Immortal Sweat Gland Cell Linementioning

confidence: 90%

The evolution of eccrine sweat gland research towards developing a model for human sweat gland function

Bovell

2018

Experimental Dermatology

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For several decades now, researchers, professional bodies, governments, and journals such as the journal of Experimental Dermatology have worked to reduce the number of animals used in experimentation. This review centres on investigations into how human sweat glands produce sweat and how that research has evolved over the years. It is hoped that this review will show that as methodologies advanced, sweat gland research has come to rely less and less on a variety of animal models as investigative tools and information is being primarily obtained through human and mouse material, with a view to further reductions in using animal models.

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Section: Immortal Sweat Gland Cell Linementioning

confidence: 90%

The evolution of eccrine sweat gland research towards developing a model for human sweat gland function

Bovell

2018

Experimental Dermatology

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“…However, oxytocin elicited electrophysiological responses in a human immortalized sweat gland cell line. The results were implicated in the context that oxytocin stimulates natriuresis in some species 19…”

Section: Principal Adjustments To Hot Arid Conditionsmentioning

confidence: 92%

Fluid Balance in Ruminants: Adaptation to External and Internal Challenges

Olsson

2005

Annals of the New York Academy of Sciences

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Ruminants are widespread in hot, arid regions. This demands adaptation to large circadian temperature fluctuations and recurrent periods of food and water shortage. Pregnancy and lactation add to the demands on the adaptive mechanisms due to the greater need for food, water, and electrolytes. The blood volume increases to meet the requirements of the fetoplacental unit and the mammary glands. Unlike urine, the milk cannot be concentrated by antidiuretic hormone (vasopressin). During water deprivation, lactating animals therefore become dehydrated more rapidly than nonlactating animals. Nevertheless, desert-adapted lactating ruminants endure frequent periods of water deprivation without incurring bad health. For the offspring living in hot and dry conditions, it is an advantage that the milk is not concentrated, even if the mother has a high antidiuretic hormone concentration to enable her to concentrate the urine. Since ruminants are prey, they need to drink rapidly when they get access to water. The forestomach allows the animals to store water in the reticulorumen. There is no danger of water intoxication even if they drink to satisfaction in a couple of minutes after having lost as much as 30% of their body weight.

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“…Electrophysiological studies showed that monolayers of the NCL-SG3 cell line respond to ATP with a transient transepithelial potential change with a more pronounced response to apical than basal application (Ring and Mö rk, 1997). Extracellular ATP, but not UTP, via P2Y receptors, caused a decrease in Cl À and K þ in primary cultures of reabsorptive ducts of human sweat glands studied with X-ray microanalysis (Hongpaisan and Roomans, 1998).…”

Section: Sweat Glandsmentioning

confidence: 99%

Purinergic Signaling in Healthy and Diseased Skin

Burnstock

Knight

Greig

2012

Journal of Investigative Dermatology

125

133

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Adenosine 5'-triphosphate and adenosine receptors have been identified in adult and fetal keratinocytes, fibroblasts, melanocytes, mast cells, Langerhans cells, and Meissner's corpuscles, as well as in hair follicles, sweat glands, and smooth muscle and endothelial cells of skin vessels. Purinergic signaling is involved in skin pathology, including inflammation, wound healing, pain, psoriasis, scleroderma, warts, and skin cancer.

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Electrophysiological Responses to Oxytocin and ATP in Monolayers of a Human Sweat Gland Cell Line

Cited by 17 publications

References 18 publications

The evolution of eccrine sweat gland research towards developing a model for human sweat gland function

The evolution of eccrine sweat gland research towards developing a model for human sweat gland function

Fluid Balance in Ruminants: Adaptation to External and Internal Challenges

Purinergic Signaling in Healthy and Diseased Skin

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