Electrophysiological study of face inversion effects in Williams syndrome

Nakamura, Miho; Watanabe, Shoko; Inagaki, Masumi; Hirai, Masahiro; Miki, Kazuo; Honda, Yukiko; Kakigi, Ryusuke

doi:10.1016/j.braindev.2012.05.010

Cited by 8 publications

(2 citation statements)

References 31 publications

(55 reference statements)

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“…Only a few brain imaging studies investigated brain activation in WS during face encoding. Electroencephalography (EEG) and magnetencephalography (MEG) during processing of upright and inverted faces reveal a number of alterations in WS individuals as compared with TD controls ( Mills et al, 2000 ; Nakamura et al, 2013 ). WS individuals exhibit less functional magnetic resonance imaging (fMRI) brain activation in the primary and secondary visual cortices ( Mobbs et al, 2004 ), and in early visual areas of the face processing network ( Binelli et al, 2016 ).…”

Section: Discussionmentioning

confidence: 99%

Social Cognition in Williams Syndrome: Face Tuning

et al. 2016

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Many neurological, neurodevelopmental, neuropsychiatric, and psychosomatic disorders are characterized by impairments in visual social cognition, body language reading, and facial assessment of a social counterpart. Yet a wealth of research indicates that individuals with Williams syndrome exhibit remarkable concern for social stimuli and face fascination. Here individuals with Williams syndrome were presented with a set of Face-n-Food images composed of food ingredients and in different degree resembling a face (slightly bordering on the Giuseppe Arcimboldo style). The primary advantage of these images is that single components do not explicitly trigger face-specific processing, whereas in face images commonly used for investigating face perception (such as photographs or depictions), the mere occurrence of typical cues already implicates face presence. In a spontaneous recognition task, participants were shown a set of images in a predetermined order from the least to most resembling a face. Strikingly, individuals with Williams syndrome exhibited profound deficits in recognition of the Face-n-Food images as a face: they did not report seeing a face on the images, which typically developing controls effortlessly recognized as a face, and gave overall fewer face responses. This suggests atypical face tuning in Williams syndrome. The outcome is discussed in the light of a general pattern of social cognition in Williams syndrome and brain mechanisms underpinning face processing.

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Section: Discussionmentioning

confidence: 99%

Social Cognition in Williams Syndrome: Face Tuning

et al. 2016

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“…MEG was first introduced to the scientific community in 1972 [1], and it has undergone substantial technological advances ever since. Modern multichannel, whole-head systems provide reliable, fast, and patient friendly scanning that is increasingly being used for clinically oriented research into a wealth of mental disorders and abnormal conditions, such as adult and pediatric epilepsy [2–6], autism [7, 8], schizophrenia [9], Williams syndrome [10], Landau-Kleffner syndrome [11], Alzheimer's disease [12, 13], depression [14], attention deficit hyperactivity disorder [15, 16], and dyslexia [17]. Moreover, MEG has been used to study neuronal change and reorganization following stroke [18], head trauma [19], and drug administration [20].…”

Section: Introductionmentioning

confidence: 99%

Magnetoencephalography: Fundamentals and Established and Emerging Clinical Applications in Radiology

Braeutigam

2013

ISRN Radiology

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Magnetoencephalography is a noninvasive, fast, and patient friendly technique for recording brain activity. It is increasingly available and is regarded as one of the most modern imaging tools available to radiologists. The dominant clinical use of this technology currently centers on two, partly overlapping areas, namely, localizing the regions from which epileptic seizures originate, and identifying regions of normal brain function in patients preparing to undergo brain surgery. As a consequence, many radiologists may not yet be familiar with this technique. This review provides an introduction to magnetoencephalography, discusses relevant analytical techniques, and presents recent developments in established and emerging clinical applications such as pervasive developmental disorders. Although the role of magnetoencephalography in diagnosis, prognosis, and patient treatment is still limited, it is argued that this technology is exquisitely capable of contributing indispensable information about brain dynamics not easily obtained with other modalities. This, it is believed, will make this technology an important clinical tool for a wide range of disorders in the future.

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Social Information Processing in Williams Syndrome

Key

Katzenstein

2018

International Review of Research in Developmental Disabilities

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Electrophysiological study of face inversion effects in Williams syndrome

Cited by 8 publications

References 31 publications

Social Cognition in Williams Syndrome: Face Tuning

Social Cognition in Williams Syndrome: Face Tuning

Magnetoencephalography: Fundamentals and Established and Emerging Clinical Applications in Radiology

Social Information Processing in Williams Syndrome

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