Electrophysiology and Biophysics of the Squid Giant Axon

Adelman, William J.; Gilbert, Daniel L.

doi:10.1007/978-1-4899-2489-6_7

Cited by 10 publications

(3 citation statements)

References 123 publications

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“…In the simulations, the resistance per surface area of the bath is calculated from the height of the bath and the bath resistivity. All experimental data presented here are from the axons with higher than 100 mV amplitude of the intracellular potential (Adelman and Gilbert, 1990) at high ASW level and with <0.3 mV difference between the amplitudes of the intracellular APs at the beginning and after the end of a series of recording when the bath was refilled to the initial level. The membrane potential, Vm, is derived from the difference between the intracellular and the extracellular potential recordings, which are relative to their resting states.…”

Section: Resultsmentioning

confidence: 99%

Effects of bath resistance on action potentials in the squid giant axon: myocardial implications

Wikswo

1997

Biophysical Journal

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This study presents a simplified version of the quasi-one-dimensional theory (Wu, J., E. A. Johnson, and J. M. Kootsey. 1996. A quasi-one-dimensional theory for anisotropic propagation of excitation in cardiac muscle. Biophys. J. 71:2427-2439) with two components of the extracellular current, along and perpendicular to the axis, and a simulation and its experimental confirmation for the giant axon of the squid. By extending the one-dimensional core conductor cable equations, this theory predicts, as confirmed by the experiment, that the shapes of the intracellular and the extracellular action potentials are related to the resistance of the bath. Such a result was previously only expected by the field theories. The correlation between the shapes of the intracellular and the extracellular potentials of the giant axon of the squid resembles that observed during the anisotropic propagation of excitation in cardiac muscle. Therefore, this study not only develops a quasi-one-dimensional theory for a squid axon, but also provides one possible factor contributing to the anisotropic propagation of action potentials in cardiac muscle.

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Section: Resultsmentioning

confidence: 99%

Effects of bath resistance on action potentials in the squid giant axon: myocardial implications

Wikswo

1997

Biophysical Journal

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“…Animal models are often used as substitutes for human models in investigations (Van Zutphen, Barumans, & Beyneen, 1993). The large diameter of the squid axon makes it an excellent model to investigate bioelectrical response to specific stimuli such as ketones (Adelman & Gilbert, 1990). Thus, Elliott and associates investigated the effects of two ketones, methyl keptyl ketone and methyl butyl ketone, on the sodium m e n t in the axon of a squid.…”

Section: Increased Comfort In the Terminally Dehydrated Patientmentioning

confidence: 99%

Dehydration and Hydration in the Terminally Ill: Care Considerations

Jackonen

1997

Nursing Forum

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Debate continues about whether to withhold or withdraw intravenous, subcutaneous, or nasogastric hydration in the terminally ill. Nurses may be confronted with situations where the terminally ill patient or family must make a decision regarding hydration. Therefore, nurses must be knowledgeable about terminal dehydration literature and research. This article is a review of the literature on terminal dehydration. The focus is on the definition of terminal dehydration, physiological benefits and disadvantages of terminal dehydration, rationale for hydrating, review of research in terminal dehydration, physiological basis for comfort in the terminally dehydrated, and suggestions for research and practice.

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“…A thorough review of the older literature on classical electrophysiology of the giant axon is given by Adelman and Gilbert [1]. Collections of more recent papers on a variety of topics concerning the giant axon system can be found in several volumes [2,3].…”

Section: Introductionmentioning

confidence: 99%

Identified Ion Channels in the Squid Nervous System

Rosenthal

Gilly²

2003

Neurosignals

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Our modern understanding of channels as discrete voltage-sensitive and ion-selective entities comes largely from a series of classical studies using the squid giant axon. This system has also been critical for understanding how transporters and synaptic transmission operate. This review outlines attempts to assign molecular identities to the extensively studied physiological properties of this system. As it turns out, this is no simple task. Molecular candidates for voltage-gated Na⁺, K⁺, and Ca²⁺ channels, as well as ion transporters have been isolated from the squid nervous system. Both physiological and molecular approaches have been used to equate these cloned gene products with their native counterparts. In the case of the delayed rectifier K⁺ conductance, the most thoroughly studied example, two major issues further complicate the equation. First, the ability of K⁺ channel monomers to form heteromultimers with unique properties must be considered. Second, squid K⁺ channel mRNAs are extensively edited, a process that can generate a wide variety of channel proteins from a common gene. The giant axon system is beginning to play an important role in understanding the biological relevance of this latter process.

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Electrophysiology and Biophysics of the Squid Giant Axon

Cited by 10 publications

References 123 publications

Effects of bath resistance on action potentials in the squid giant axon: myocardial implications

Effects of bath resistance on action potentials in the squid giant axon: myocardial implications

Dehydration and Hydration in the Terminally Ill: Care Considerations

Identified Ion Channels in the Squid Nervous System

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