Electrophysiology and Optical Coherence Tomography to Evaluate Parkinson Disease Severity

García‐Martín, Elena; Rodríguez-Mena, Diego; Satué, María; Almárcegui, Carmen; Dolz, Isabel; Alarcia, Raquel; Seral, M; Polo, Vicente; Larrosa, José M.; Júlvez, Luis Pablo

doi:10.1167/iovs.13-13062

Cited by 104 publications

(101 citation statements)

References 47 publications

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“…44 Many parts of the visual system have been implicated as the cause for visual deficits, such as the retina, where thinning of the inner retinal nerve fiber layer and decreased dopamine concentration seem to mirror the loss of dopaminergic neurons in the basal ganglia. 2,45,46 Pattern electroretinogram studies in PD subjects have shown significant loss at midspatial frequencies of 4 cyc/deg, corroborating our findings. 47 With the addition of motion, both PD and control subjects improved their contrast sensitivity at low spatial frequencies.…”

Section: Discussionsupporting

confidence: 88%

Visual Contrast Sensitivity in Early-Stage Parkinson's Disease

Ming

Palidis

Spering

et al. 2016

Invest. Ophthalmol. Vis. Sci.

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PURPOSE. Visual impairments are frequent in Parkinson's disease (PD) and impact normal functioning in daily activities. Visual contrast sensitivity is a powerful nonmotor sign for discriminating PD patients from controls. However, it is usually assessed with static visual stimuli. Here we examined the interaction between perception and eye movements in static and dynamic contrast sensitivity tasks in a cohort of mildly impaired, early-stage PD patients. METHODS.Patients (n ¼ 13) and healthy age-matched controls (n ¼ 12) viewed stimuli of various spatial frequencies (0-8 cyc/deg) and speeds (08/s, 108/s, 308/s) on a computer monitor. Detection thresholds were determined by asking participants to adjust luminance contrast until they could just barely see the stimulus. Eye position was recorded with a videobased eye tracker. RESULTS.Patients' static contrast sensitivity was impaired in the intermediate spatial-frequency range and this impairment correlated with fixational instability. However, dynamic contrast sensitivity and patients' smooth pursuit were relatively normal. An independent component analysis revealed contrast sensitivity profiles differentiating patients and controls.CONCLUSIONS. Our study simultaneously assesses perceptual contrast sensitivity and eye movements in PD, revealing a possible link between fixational instability and perceptual deficits. Spatiotemporal contrast sensitivity profiles may represent an easily measurable metric as a component of a broader combined biometric for nonmotor features observed in PD.

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Section: Discussionsupporting

confidence: 88%

Visual Contrast Sensitivity in Early-Stage Parkinson's Disease

Ming

Palidis

Spering

et al. 2016

Invest. Ophthalmol. Vis. Sci.

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show abstract

“…In this context, optical coherence tomography (OCT), a non-invasive imaging technique, provides reproducible, high-resolution cross-sectional imaging of the retinal nerve fiber layer (RNFL) and optic nerve head topography, providing an objective tool to diagnose axonal damage and thus constituting a "window into the brain" (London et al, 2013). A significant reduction in peripapillary RNFL thickness has been reported in patients with various neurological disorders such as multiple sclerosis (Sergott et al, 2007;Thrower, 2007), Alzheimer's disease (Parisi et al, 2001;Berisha et al, 2007;Marziani et al, 2013;Larrosa et al, 2014;Ascaso et al, 2014) or Parkinson's disease (Inzelberg et al, 2004;Hajee et al, 2009;Garcia-Martin et al, 2014;Jimenez et al, 2014), suggesting that this technique may also prove to be useful in other neuropsychiatric disorders.…”

Section: Introductionmentioning

confidence: 99%

Retinal nerve fiber layer and macular thickness in patients with schizophrenia: Influence of recent illness episodes

Ascaso

Rodríguez‐Jiménez

Cabezon

et al. 2015

Psychiatry Research

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“…The results of previous OCT studies are inconclusive. Some studies revealed RNFL thinning in PD cases [13][14][15][16], while other does not support this [17][18][19][20]. The reason of result discrepancies may be qualification of PD patients with glaucoma to the analysis, which has proven influence on RNFL thickness.…”

Section: Discussionmentioning

confidence: 99%