Electrophysiology and Single Cells

Juhász, Gábor; Mittli, Dániel; Tukacs, Vanda; Kékesi, Katalin A.

doi:10.1007/978-1-0716-2525-5_10

Cited by 1 publication

(2 citation statements)

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“…In vitro preparations are extremely rapid, flexible, and available methods for long-standing problems in epilepsy research including ictogenesis and drug resistance. We have been able to gain molecular, cellular, and electrophysiologic insights into brain function with detail that is not possible in vivo thanks to in vitro brain tissue preparations, which enable the suitable and reasonable research of brain networks ( 6 ). It has been possible to produce electrical activity in vitro that is similar to the electrographic activity found in individuals with epilepsy using preparations from both rodent and human postsurgical tissue.…”

Section: Introductionmentioning

confidence: 99%

“…2 trophysiologic insights into brain function with detail that is not possible in vivo thanks to in vitro brain tissue preparations, which enable the suitable and reasonable research of brain networks (6). It has been possible to produce electrical activity in vitro that is similar to the electrographic activity found in individuals with epilepsy using preparations from both rodent and human postsurgical tissue.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

High and Low-Frequency Stimulation Effect on Epileptiform Activity in Brain Slices

Khodadadi

Zare

Ghasemi

et al. 2023

MJIRI

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Background Neurostimulation is one of the new therapeutic approaches in patients with drug-resistant epilepsy, and despite its high efficiency, its mechanism of action is still unclear. On the one hand, electrical stimulation in the human brain is immoral; on the other hand, the creation of the epilepsy model in laboratory animals affects the entire brain network. As a result, one of the ways to achieve the neurostimulation mechanism is to use epileptiform activity models In vitro. In vitro models, by accessing the local network from the whole brain, we can understand the mechanisms of action of neurostimulation. Methods A literature search using scientific databases including PubMed, Google Scholar, and Scopus, using "Neurostimulation" and "epileptiform activity" combined with "high-frequency stimulation", " low-frequency stimulation ", and "brain slices” as keywords were conducted, related concepts to the topic gathered and are used in this paper. Results Electrical stimulation causes neuronal depolarization and the release of GABAA, which inhibits neuronal firing. Also, electrical stimulation inhibits the nervous tissue downstream of the stimulation site by preventing the passage of nervous activity from the upstream to the downstream of the axon. Conclusion Neurostimulation techniques consisting of LFS and HFS have a potential role in treating epileptiform activity, with some studies having positive results. Further investigations with larger sample sizes and standardized outcome measures can be conducted to validate the results of previous studies.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%