Electrophysiology in Glaucoma Assessment

Graham, Stuart L.; Fortune, Brad

doi:10.1016/b978-0-7020-5193-7.00014-5

Cited by 2 publications

(8 citation statements)

References 128 publications

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“…43–45 If IOP is very high, the full-field ERG may be extinguished, and although this has negative prognostic significance, in the authors’ experience it is still possible for vision to be temporarily regained once IOP returns to normal and adequate perfusion to the retina is returned. 24,43–45 …”

Section: Techniques That Evaluate the Visual Capabilities Of The Eyementioning

confidence: 89%

“…43 The standard full-field electroretinogram (ERG), which is predominately driven by the outer retina, is generally not helpful in the diagnosis or treatment of glaucoma, especially PACG, in which the IOP increase may be very sudden. 43–45 If IOP is very high, the full-field ERG may be extinguished, and although this has negative prognostic significance, in the authors’ experience it is still possible for vision to be temporarily regained once IOP returns to normal and adequate perfusion to the retina is returned. 24,43–45 …”

Section: Techniques That Evaluate the Visual Capabilities Of The Eyementioning

confidence: 99%

“…43–45 Initial testing in humans and dogs suggests that the PERG is more sensitive than the full-field ERG to IOP increases. 43–45 …”

Section: Techniques That Evaluate the Visual Capabilities Of The Eyementioning

confidence: 99%

“…43 Standard white light, pattern, or flicker-based VEPs have been investigated but the results are variable enough across studies to indicate that VEP does not perform well enough to be useful clinically. 43 …”

Section: Techniques That Evaluate the Visual Capabilities Of The Eyementioning

confidence: 99%

“…43 The great advantage of this technique is that it one can record a detailed multifocal ERG (mfERG) that shows a topographic distribution of the signal amplitudes instead of just a single mass response representing the average response across the entire retina. This technique allows for the detection of regional midperipheral retinal damage that occurs in the earlier stages of glaucoma and these correspond to regions of visual field loss.…”

Section: Techniques That Evaluate the Visual Capabilities Of The Eyementioning

confidence: 99%

See 4 more Smart Citations

Clinical Signs and Diagnosis of the Canine Primary Glaucomas

Miller

Bentley

2015

Veterinary Clinics of North America: Small Animal Practice

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Section: Techniques That Evaluate the Visual Capabilities Of The Eyementioning

confidence: 89%

Section: Techniques That Evaluate the Visual Capabilities Of The Eyementioning

confidence: 99%

“…43–45 Initial testing in humans and dogs suggests that the PERG is more sensitive than the full-field ERG to IOP increases. 43–45 …”

Section: Techniques That Evaluate the Visual Capabilities Of The Eyementioning

confidence: 99%

Section: Techniques That Evaluate the Visual Capabilities Of The Eyementioning

confidence: 99%

Section: Techniques That Evaluate the Visual Capabilities Of The Eyementioning

confidence: 99%

See 3 more Smart Citations

Clinical Signs and Diagnosis of the Canine Primary Glaucomas

Miller

Bentley

2015

Veterinary Clinics of North America: Small Animal Practice

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The Effect of Simulated Visual Field Loss on Optokinetic Nystagmus

Doustkouhi

Turnbull

Dakin

2020

Trans. Vis. Sci. Tech.

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Citation: Doustkouhi SM, Turnbull PRK, Dakin SC. The effect of simulated visual field loss on optokinetic nystagmus. Trans Vis Sci Tech. 2020;9(3):25, https://doi.org/10. 1167/tvst.9.3.25 Purpose: Assessment of functional vision across the visual field is hampered by a reliance on patients'subjective judgement of the presence of a stimulus, and the accompanying demands (time and attention) this places on them. As a first step toward determining whether an objective measure of an involuntary eye movement (optokinetic nystagmus [OKN]) could provide an objective measure of field loss, we determined how various measures of OKN depend on the extent of simulated visual field loss (SVFL). Methods:We used infrared eye-tracking to measure the eye movements of 16 healthy participants viewing horizontally translating 2-dimensional noise patterns over trials of varying contrasts and different levels of SVFL. We quantified the strength of OKN by estimating the velocity of tracking eye movements compared to the stimulus (OKN gain). These measurements were made using an open-loop SVFL paradigm, where a varying amount of gaze-contingent peripheral stimuli was occluded.Results: Full-field stimulation led to an average OKN gain of 0.92 ± 0.15. This value fell steadily with increasing SVFL to a value of 0.38 ± 0.20 when the periphery was not stimulated at all (i.e., the stimulus was a 5-deg. diameter foveal patch). We note considerable individual variation in OKN gain in all conditions. Conclusions:Measuring the extent of visual field loss using an objective measure of OKN gain is feasible.Translational Relevance: Simulated visual field loss reduces optokinetic nystagmus, but further refinement of this technique would be required to overcome individual differences and to pick up clinically relevant field defects.

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Electrophysiology in Glaucoma Assessment

Cited by 2 publications

References 128 publications

Clinical Signs and Diagnosis of the Canine Primary Glaucomas

Clinical Signs and Diagnosis of the Canine Primary Glaucomas

The Effect of Simulated Visual Field Loss on Optokinetic Nystagmus

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