Electrophysiology monitoring

Thompson, James W.G.; Kosofsky, Barry E.; Dhamala, Elvisha; Duggan, Ryan

doi:10.1016/b978-0-12-816346-7.00008-7

Biomarkers for Traumatic Brain Injury 2020

DOI: 10.1016/b978-0-12-816346-7.00008-7

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Electrophysiology monitoring

James W.G. Thompson¹,

Barry E. Kosofsky

Elvisha Dhamala

et al.

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2023

2024

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Cited by 2 publications

(1 citation statement)

References 112 publications

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“…Measuring the temporal trajectory of neurocognitive (dys)function is particularly advantageous since cognitive processing is extremely fast (and thus not fully capturable via other neuroimaging methods), where the temporal encoding of information is essential for synaptic plasticity during executive functioning, emotion control, inhibition, learning, and memory processing. ERP components in humans can be divided into two broad categories: (1) early “sensory” or “exogenous” components that peak amplitude before (or around) ~ 100 ms post-stimulus, and (2) late “cognitive” or “endogenous” components that peak from 100 ms onwards and represent more elaborative information processing (Thompson et al, 2020; Tivadar & Murray, 2019). Impairment or dysregulation of ERP components can represent phenotypic markers of neurocognitive deficit and synaptic dysfunction.…”

mentioning

confidence: 99%

Neurocognitive Impairment in Non-Central Nervous System Cancer Survivors

Schoenberg,

Mohr,

Kilpatrick

et al. 2024

Journal of Psychophysiology

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Cancer and its treatments entail a profound inflammatory response of the central nervous system (CNS). This intense neurotoxic process can lead to significant neurocognitive impairment even in non-CNS cancers. Few studies have examined this domain, and data available is based on limited designs using neuropsychological assessments comprising self-report or traditional testing batteries that capture basic response data. Here, we leverage cognitive electrophysiology, specifically Event-Related Potentials (ERPs), to examine and delineate neurocognitive impairments in non-CNS cancer survivors. Eleven survivors, who were on average 4.6 years in remission from head and neck cancer and 10 matched healthy controls underwent standardized cognitive and emotional “Go-Nogo” paradigms concomitant to EEG recording. Significant differences in amplitude morphology in the very early ERP components (C1, N1, P1) and middle ERP component (N2), were apparent between non-CNS cancer survivors and controls. Later ERP components (P3, N4) did not show amplitude differences. Non-CNS cancer survivors yielded faster latencies in the early components for pain-related stimuli during the emotional paradigm, albeit tended to yield slower ERP latencies overall across both experiments. These findings suggest that early gating and inhibitory control are dysregulated in non-CNS cancer survivors, which can impact executive functioning and cognitive processing involved in everyday activities for many years post-treatment. The findings do not fully align with ERP morphologies associated with neurocognitive impairment in degenerative conditions (such as dementia and Alzheimer’s disease), affecting later-stage ERP components. Our initial results suggest that (1) cognitive impairments in cancer survivors do not follow a degenerative trajectory, (2) rather are in line with “lesion” related damage (such as stroke, epilepsy), and as such, (3) have the potential for treatments involving neurocognitive plasticity.

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confidence: 99%

Neurocognitive Impairment in Non-Central Nervous System Cancer Survivors

Schoenberg,

Mohr,

Kilpatrick

et al. 2024

Journal of Psychophysiology

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Binaural Beat Effects on Attention: A Study Based on the Oddball Paradigm

Cepeda-Zapata,

Corona-González,

Alonso-Valerdi

et al. 2023

Brain Topogr

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Electrophysiology monitoring

Cited by 2 publications

References 112 publications

Neurocognitive Impairment in Non-Central Nervous System Cancer Survivors

Neurocognitive Impairment in Non-Central Nervous System Cancer Survivors

Binaural Beat Effects on Attention: A Study Based on the Oddball Paradigm

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