Electrophysiology of Supramedullary Neurons in <i>Spheroides maculatus  </i>

Bennett, Michael V. L.; Crain, Stanley M.; Grundfest, Harry

doi:10.1085/jgp.43.1.189

Cited by 39 publications

(10 citation statements)

References 34 publications

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“…Such an alteration in spike duration also occurs during the repetitive firing of neurons of the puffer fish in the absence of TEA (Bennett et al, 1959). These observations suggest that, along with facilitation, a depression of spike duration also occurs during repetitive stimulation.…”

Section: Discussionmentioning

confidence: 68%

Calcium‐dependent increase in spike duration during repetitive firing of Aplysia axon in the presence of TEA

Horn

Miller

1978

J. Neurobiol.

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Repetitive stimulation was studied in the axon of the giant neuron, R2, of Aplysia in the presence of TEA. In 25 or 50 mM extracellular TEA, a plateau develops on the axon spike during repetitive stimulation at frequencies greater than 3/sec. The plateau in extracellular TEA is inhibited by 30 mM CoCl2 or 1 mM CdCl2, and is enhanced by raising the Ca concentration. Intracellular TEA induces a plateau on the axon spike at frequencies less than 1/30sec. This plateau increases in duration with repetitive stimulation at higher frequencies and is inhibited by 30 mM CoCl2 or 1 mM CdCl2. The increase in spike duration during repetitive firing in the presence of TEA is indicative of an increased entry of Ca during the spike train.

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Section: Discussionmentioning

confidence: 68%

Calcium‐dependent increase in spike duration during repetitive firing of Aplysia axon in the presence of TEA

Horn

Miller

1978

J. Neurobiol.

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“…Further hyperpolarization reduced the initial component somewhat, but not to the extent of the decrease of the ADP. These observations will be discussed more fully in the subsequent papers (5,6). …”

Section: Site Of Blockade Of Antii)romic Invasionmentioning

confidence: 83%

Electrophysiology of Supramedullary Neurons in Spheroides maculatus

Bennett

Crain

Grundfest

1959

The Journal of General Physiology

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This series of three papers presents data on a system of neurons, the large supramedullary ceils (SMC) of the puffer, Spheroides maculatus, in terms of the physiological properties of the individual ceils, of their afferent and efferent connections, and of their interconnections. Some of these findings are verified by available anatomical data, but others suggest structures that must be sought for in the light of the demonstration that these cells are not sensory neurons.Analysis on so broad a scale was made possible by the accessibility of the cells in a compact cluster on the dorsal surface of the spinal cord. Simultaneous recordings were made intracellularly and extraceilularly from individual cells or from several, frequently with registration of the afferent or efferent activity as well. The passive and active electrical properties of the SMC are essentially similar to those of other neurons, but various response characteristics have been observed which are related to different excitabilities of different parts of the neuron, and to specific anatomical features.The SMC produce spikes to direct stimuli by intracellular depolarization, or by indirect synaptic excitation from many afferent paths, including tactile stimulation of the skin. Responses that were evoked by intracellular stimulation of a single call cause an efferent discharge bilaterally in many dorsal roots, but not in the ventral. Sometimes several distinct spikes occurred in the same root, and behaved independently. Thus, a number of axons are efferent from each From the

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“…On the other hand, in axons, free electrons within an electrolyte solution are much fewer than ion particles. Also, the resistance of the lipid bilayer, which is known to be practically an insulator, is too high (500–10,000 [Ω/cm 2 ]) to freely carry electric charges within it compared to intra- and extra-cellular fluids (Bennett et al, 1959 ; Turner and Schwartzkroin, 1980 ; Shepherd et al, 1985 ).…”

Section: Introductionmentioning

confidence: 99%

New Theoretical Model of Nerve Conduction in Unmyelinated Nerves

Akaishi

2017

Front. Physiol.

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Nerve conduction in unmyelinated fibers has long been described based on the equivalent circuit model and cable theory. However, without the change in ionic concentration gradient across the membrane, there would be no generation or propagation of the action potential. Based on this concept, we employ a new conductive model focusing on the distribution of voltage-gated sodium ion channels and Coulomb force between electrolytes. Based on this new model, the propagation of the nerve conduction was suggested to take place far before the generation of action potential at each channel. We theoretically showed that propagation of action potential, which is enabled by the increasing Coulomb force produced by inflowing sodium ions, from one sodium ion channel to the next sodium channel would be inversely proportionate to the density of sodium channels on the axon membrane. Because the longitudinal number of sodium ion channel would be proportionate to the square root of channel density, the conduction velocity of unmyelinated nerves is theoretically shown to be proportionate to the square root of channel density. Also, from a viewpoint of equilibrium state of channel importation and degeneration, channel density was suggested to be proportionate to axonal diameter. Based on these simple basis, conduction velocity in unmyelinated nerves was theoretically shown to be proportionate to the square root of axonal diameter. This new model would also enable us to acquire more accurate and understandable vision on the phenomena in unmyelinated nerves in addition to the conventional electric circuit model and cable theory.

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Electrophysiology of Supramedullary Neurons in Spheroides maculatus

Cited by 39 publications

References 34 publications

Calcium‐dependent increase in spike duration during repetitive firing of Aplysia axon in the presence of TEA

Calcium‐dependent increase in spike duration during repetitive firing of Aplysia axon in the presence of TEA

Electrophysiology of Supramedullary Neurons in Spheroides maculatus

New Theoretical Model of Nerve Conduction in Unmyelinated Nerves

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