Electropolymerized molecular imprinting on glassy carbon electrode for voltammetric detection of dopamine in biological samples

Kiss, László; David, Vasile; David, Iulia Gabriela; Lazăr, Paul; Mihailciuc, Constantin; Stamatin, I.; Ciobanu, Adela Magdalena; Stefanescu, Cristian Dragos; Nagy, Lı́via; Nagy, Géza; Ciucu, Anton Alexandru

doi:10.1016/j.talanta.2016.07.024

Cited by 24 publications

(10 citation statements)

References 61 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In the equation D (cm 2 s −1 ) is the diffusion coefficient, c (mol cm −3 ) is the bulk concentration of DA, A is the electrochemical active electrode area and n is the transferred electron number [34]. With the value of slope and the other necessary values, D value of 4.452×10 −5 cm 2 s −1 was obtained, in accordance with the literature data [34].…”

Section: Resultssupporting

confidence: 81%

Development of an Electrochemical Sensor for Selective Determination of Dopamine Based on Molecularly Imprinted Poly(p‐aminothiophenol) Polymeric Film

Ermiş

Tinkiliç

2021

Electroanalysis

View full text Add to dashboard Cite

In this study, a molecularly imprinted electrochemical sensor (MIP/DA) was investigated for selective and sensitive determination of dopamine (DA) by electrochemical polymerization of p‐aminothiophenol in the presence of DA on gold electrode. According to electrochemical behaviour of the sensor, gained through cyclic voltammetry (CV) and electrochemical impedance spectroscopy (EIS), MIP/DA sensor showed distinctive electron transfer characteristics in comparison to the non‐imprinted (NIP/DA) sensor. Besides the MIP/DA sensor showed high selectivity for dopamine through its analyte specific cavities. The sensor had a broad working range of 5.0×10−8–2.0×10−7 M with a limit of detection (LOD) of 1.8×10−8 M and the developed sensor was successfully applied for determination of dopamine in pharmaceutical samples.

show abstract

Section: Resultssupporting

confidence: 81%

Development of an Electrochemical Sensor for Selective Determination of Dopamine Based on Molecularly Imprinted Poly(p‐aminothiophenol) Polymeric Film

Ermiş

Tinkiliç

2021

Electroanalysis

View full text Add to dashboard Cite

show abstract

“…Kiss et al were developed molecularly imprinted polymerbased electrochemical sensor for the determination of dopamine in 2016. The stability of the electrodes decreased by 2% after 1 week, 6% after 2 weeks, and about 18% after 1 month [59]. It can be said that the results obtained as a result of our study can compete with the polymeric based electrochemical sensor samples in the literature.…”

Section: Nanobiosensor Characteristics and Methods Validationmentioning

confidence: 57%

A New Nanomaterial Based Biosensor for MUC1 Biomarker Detection in Early Diagnosis, Tumor Progression and Treatment of Cancer

Ulucan‐Karnak

Akgöl

2021

Nanomanufacturing

View full text Add to dashboard Cite

Early detection of cancer disease is vital to the successful treatment, follow-up and survival of patients, therefore sensitive and specific methods are still required. Mucin 1 (MUC1) is a clinically approved biomarker for determining the cancer that is a type I transmembrane protein with a dense glycosylated extracellular domain extending from the cell surface to 200–500 nm. In this study, nanopolymers were designed with a lectin affinity-based recognition system for MUC1 detection as a bioactive layer on electrochemical biosensor electrode surfaces. They were synthesized using a mini emulsion polymerization method and derivatized with triethoxy-3-(2-imidazolin-1-yl) propylsilane (IMEO) and functionalized with Concanavalin a Type IV (Con A) lectin. Advanced characterization studies of nanopolymers were performed. The operating conditions of the sensor system have been optimized. Biosensor validation studies were performed. Real sample blood serum was analyzed and this new method compared with a commercially available medical diagnostic kit (Enzyme-Linked ImmunoSorbent Assay-ELISA). The new generation nanopolymeric material has been shown to be an affordable, sensitive, reliable and rapid device with 0.1–100 U/mL linear range and 20 min response time.

show abstract

“…Among the MIPs realized on bare electrodes, an LOD of 1.04 µM was obtained on gold modified with poly(pyrrole) [37]. Lower detection limits in the nanomolar range were achieved in the case of poly(ethacridine) [38], and poly(pyrrole-phenylboronic acid) [39], both deposited on glassy carbon. In the first case, the sensor was applied for DA determination in human sera with good recoveries, even if no data were displayed on its selectivity.…”

Section: Analytical Characterization Of the Mipmentioning

confidence: 99%

Electrosynthesized Poly(o-aminophenol) Films as Biomimetic Coatings for Dopamine Detection on Pt Substrates

et al. 2021

View full text Add to dashboard Cite

Dopamine (DA) is a neurotransmitter, and its levels in the human body are associated with serious diseases. The need for a suitable detection method in medical practice has encouraged the development of electrochemical sensors that take advantage of DA electroactivity. Molecularly imprinted polymers (MIPs) are biomimetic materials able to selectively recognize target analytes. A novel MIP sensor for DA is proposed here based on a thin film of poly(o-aminophenol) electrosynthesized on bare Pt. A fast and easy method for executing the procedure for MIP deposition has been developed based on mild experimental conditions that are able to prevent electrode fouling from DA oxidation products. The MIP exhibited a limit of detection of 0.65 μM, and appreciable reproducibility and stability. The high recognition capability of poly(o-aminophenol) towards DA allowed for the achievement of notable selectivity: ascorbic acid, uric acid, serotonin, and tyramine did not interfere with DA detection, even at higher concentrations. The proposed sensor was successfully applied for DA detection in urine samples, showing good recovery.

show abstract

Electropolymerized molecular imprinting on glassy carbon electrode for voltammetric detection of dopamine in biological samples

Cited by 24 publications

References 61 publications

Development of an Electrochemical Sensor for Selective Determination of Dopamine Based on Molecularly Imprinted Poly(p‐aminothiophenol) Polymeric Film

Development of an Electrochemical Sensor for Selective Determination of Dopamine Based on Molecularly Imprinted Poly(p‐aminothiophenol) Polymeric Film

A New Nanomaterial Based Biosensor for MUC1 Biomarker Detection in Early Diagnosis, Tumor Progression and Treatment of Cancer

Electrosynthesized Poly(o-aminophenol) Films as Biomimetic Coatings for Dopamine Detection on Pt Substrates

Contact Info

Product

Resources

About