Electroresponsive Polyacrylamide-grafted-xanthan Hydrogels for Drug Delivery

Kulkarni, Raghavendra V.; Sa, Biswanath

doi:10.1177/0883911509104475

Cited by 78 publications

(36 citation statements)

References 33 publications

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“…The presence of ionizable groups in the hydrogel elicits chemical and physical changes in the structure, thus enabling drug release [ 110 ]. Electrical stimulation of a responsive polyelectrolyte causes drug migration to the oppositely charged electrode, and contraction of the hydrogel, emanating in drug expulsion [ 111 ]. This drug movement is represented in Fig.…”

Section: Creating Composites Of Smart Hydrogels and Electroactive Polmentioning

confidence: 99%

Electroactive Polymers and Coatings

Toit

Kumar

Choonara

et al. 2016

Industrial Applications for Intelligent Polymers and Coatings

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Electroactive polymers (EAPs) and coatings (EACs) provide an expanding and progressive frontier for responsive drug delivery and the design of biomedical devices. EAPs possess the distinctive propensity to undergo a change in shape and/or size following electrical current activation. Current interest in EAPs and EACs extends to use in controlled drug delivery applications, where an "on-off" mechanism for drug releases would be optimal, as well as application in a biomedical devices and implants. This chapter explores and molecularly characterizes various EAPs such as polyaniline, polypyrrole, polythiophene, and polyethylene, which can ultimately be incorporated into responsive hydrogels in conjunction with, for example, a desired bioactive, to obtain a stimulus-controlled bioactive release system, which can be actuated by the patient, for enhanced specifi city. The institution of hybrids of conducting polymers and hydrogels has also been subjected to increasing investigation as soft EACs, which have been applied, for example, in the improvement of the mechanical and electrical performance of metallic implant electrodes. The various interconnected aspects of EAP-based systems, including their synthesis, proposed modus operandi , physical properties, as well as functionalization approaches for enhancing the performance of these systems, are delineated. The use and comparison of these EAPs and EACs alone, and in conjunction with hydrogels, is further elaborated, together with strategies for integrating electroactive components and hydrogels. Approaches for modeling and explaining the proposed modus operandi of these systems are delineated. A critical review of diverse biomedical systems implementing EAPs and EACs having application in the pharmaceutical and medical industry, specifi cally, is provided, highlighting their applications, potential advantages, and possible limitations. Ultimately, this chapter illuminates innovative approaches for enabling EAP-and EAC-based systems to attain their full clinical potential.

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Section: Creating Composites Of Smart Hydrogels and Electroactive Polmentioning

confidence: 99%

Electroactive Polymers and Coatings

Toit

Kumar

Choonara

et al. 2016

Industrial Applications for Intelligent Polymers and Coatings

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“…An electro-responsive drug delivery system was also developed using poly(acrylamide-grafted-xanthan gum) (PAAm-g-XG) hydrogel for transdermal delivery of ketoprofen [85]. When a swollen PAAm-g-XG hydrogel was placed between a pair of electrodes, a de-swelling of the hydrogel was observed in the vicinity of electrodes carrying the electric stimulus.…”

Section: Electro-responsive Polymersmentioning

confidence: 99%

Drug Delivery Systems: Smart Polymeric Materials

Cassano

Trombino

2014

Advanced Polymers in Medicine

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Over the last two decades the smart polymeric materials have involved the interest of the scientific community because they can be used in the design and formulation of dosage forms that respond, with a considerable variation of their properties, to changes in their environment. As result, these materials control the drug release into specific physiological compartments. Concerning on the environmental stimuli these include pH, temperature, light, chemicals, etc. The smart polymeric materials stimuli-responsive can be synthetics or naturals and have been used in the biotechnological, medicinal and engineering fields. The present chapter is aimed to focus the importance of this category of drug delivery systems and, in particular, it provides a summarizing overview of the range of smart polymeric materials and the drug delivery systems that exploit them.

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“…10,29 Gels that respond to two or more stimuli have also been studied. 9,22,30,31 Injectable environmentally sensitive hydrogels formed by in situ chemical polymerization are flowable aqueous solutions before administration, but once injected, rapidly gel under physiological conditions. 4,6,[32][33][34][35] The desired drug release period varies from application to application.…”

Section: Introductionmentioning

confidence: 99%

“…1,3,20 Some hydrogels, the so-called smart hydrogels, can either shrink or swell in response to different stimuli, such as pH, temperature, ionic strength, magnetic, and electrical fields or a combination of these, leading to release or uptake of drug, as appropriate. 1,[3][4][5]8,9,11,[20][21][22] Among these, hydrogels which respond to changes in temperature or pH are most widely used. 4,23 One of the most well-known thermal-responsive polymers is poly(N-isopropylacrylamide) (PNIPAAm), which exhibits a lower critical solution temperature (LCST) around 32 C in an aqueous solution.…”

Section: Introductionmentioning

confidence: 99%

Drug loading into and drug release from pH‐ and temperature‐responsive cylindrical hydrogels

Ninawe

Parulekar

2011

Biotechnology Progress

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Hydrogels that undergo deformation upon appropriate changes in pH or temperature have considerable promise as drug delivery vehicles. Drug uptake in swelling and nonswelling cylindrical hydrogels and drug release from these into a target fluid are investigated here. A mathematical model for hydrogel-solution composite, a composite of a distributed parameter system (cylindrical hydrogel) and a lumped parameter system (surrounding solution), is developed. The polymer network displacement in a swelling/deswelling hydrogel is described by a stress diffusion coupling model. The analytical solution for network displacement is used to predict solvent intake by swelling hydrogels, solvent efflux from deswelling hydrogels, and changes in pressure, porosity, and effective drug diffusivity. These in turn influence drug uptake during and after hydrogel swelling and drug release from hydrogel during and after deswelling. Numerical results illustrate benefits of hydrogel swelling for drug loading and merits of different modes of drug release. Drug uptake and drug release by temperature-responsive hydrogels are compared with those by hydrogels not subject to deformation.

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Electroresponsive Polyacrylamide-grafted-xanthan Hydrogels for Drug Delivery

Cited by 78 publications

References 33 publications

Electroactive Polymers and Coatings

Electroactive Polymers and Coatings

Drug Delivery Systems: Smart Polymeric Materials

Drug loading into and drug release from pH‐ and temperature‐responsive cylindrical hydrogels

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