Electroretinogram Changes in Acute Quinine Poisoning

Cibis, Gerhard W.; Burian, Herman M.; Blodi, Frederick C.

doi:10.1001/archopht.1973.01000050309014

Cited by 25 publications

(6 citation statements)

References 5 publications

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“…Brinton et al (1980) have suggested that quinine has a direct toxic effect on the retinal cells since when amblyopia is most severe early changes in the electroretinogram can be detected and the retinal vessles still appear normal. Similar transient early electroretinogram changes of increased a wave latency and reduced b wave amplitude have also been reported in animal experiments (Cibis et al 1973). Homer (1968) reported on 3 patients where the electroretinogram returned to normal within 48 h but was followed by a secondary decline in b wave amplitude.…”

supporting

confidence: 66%

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Two year electrophysiology follow‐up in quinine amblyopia

Moloney

Hillery

Fenton

1987

Acta Ophthalmologica

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A 19-year-old girl presenting with quinine amblyopia had serial electrophysiology studies over a 2 year period. Visually evoked responses and the electro-oculogram were abolished early. By 2 months the VER and visual acuity had returned to normal. The electroretinogram, initially mildly subnormal, became virtually abolished by 2 months. No recovery in cone function took place. Of the rods 50% regained function with normal latency by 1 year, but receptor sensitivity did not return to normal until 2 years after ingestion. The electro-oculogram also recovered slowly over a 2 year period. This pattern suggest that quinine exerts a direct toxic effect on the cells of the outer retina and pigment epithelium, as well as on the ganglion cells.

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supporting

confidence: 66%

“…Abnormalities of visually evoked potentials have been shown after quinine ingestion (Cibis et al 1973;Gangitano 8c Keltner 1980) and animal experiments (Francois et al 1972), have also demonstrated that quinine can have a toxic effect on ganglion cells.…”

mentioning

confidence: 99%

Two year electrophysiology follow‐up in quinine amblyopia

Moloney

Hillery

Fenton

1987

Acta Ophthalmologica

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“…The mechanism of hearing impairment may be simi-lar to that associated with salicylism. By analogy, quinine also induces rapid and reversible changes in the electroretinogram (Cibis et al, 1973) which are thought to result from a direct effect on retinal cell function.…”

Section: Discussionmentioning

confidence: 99%

Quinine induces reversible high‐tone hearing loss.

Roche

Silamut

Pukrittayakamee

et al. 1990

Brit J Clinical Pharma

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“…Acquired causes of negative ERGs include melanoma-associated retinopathy (MAR), central retinal artery and vein occlusions, as well as quinine-, and methanol-induced retinopathy [6][7][8][9][10]. At least 33 disorders with negative ERGs had been reported by 2001 [11], and the list has continued to grow [12][13][14][15].…”

Section: Introductionmentioning

confidence: 99%

Negative electroretinograms in the pediatric and adult population

et al. 2012

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Objective To assess the frequency of negative waveform electroretinograms (ERGs) in a tertiary referral center. Design Retrospective chart review. Participants All patients who had an ERG performed at the electrophysiology clinic at Emory University from January 1999 through March 2008 were included in the study. Methods Patients with b-wave amplitude ≤ a-wave amplitude during the dark-adapted bright flash recording, in at least one eye, were identified as having a "negative ERG". Clinical information, such as age, gender, symptoms, best corrected visual acuity, and diagnoses were recorded for these patients when available. Results A total of 1,837 patients underwent ERG testing during the study period. Of those, 73 patients had a negative ERG, for a frequency of 4.0%. Within the adult (≥ 18 years of age) and pediatric populations, the frequencies of a negative ERG were 2.5 and 7.2%, respectively. Among the 73 cases, negative ERGs were more common among male than female patients, 6.7% versus 1.8% (P < 0.0001). Negative ERGs were most common among male children and least common among female adults, 9.6% versus 1.1%, respectively, (P < 0.0001). Overall in this group of patients, the most common diagnoses associated with a negative ERG were congenital stationary night blindness (CSNB, n = 29) and X-linked retinoschisis (XLRS, n = 7). Conclusions The overall frequency of negative ERGs in this large retrospective review was 4.0%. Negative ERGs were most common among male children and least common among female adults. Despite the growing number of new diagnoses associated with negative ERGs, CSNB, and XLRS appear to be the most likely diagnoses for a pediatric patient who presents with a negative ERG.

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Electroretinogram Changes in Acute Quinine Poisoning

Cited by 25 publications

References 5 publications

Two year electrophysiology follow‐up in quinine amblyopia

Two year electrophysiology follow‐up in quinine amblyopia

Quinine induces reversible high‐tone hearing loss.

Negative electroretinograms in the pediatric and adult population

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