Electroretinographic effects of haloperidol on the mouse retina

Mizota, Atsushi

doi:10.1007/bf01371130

Cited by 7 publications

(1 citation statement)

References 13 publications

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“…The influence of fluanisone on the ERG has previously not been studied, but some information is available on similar butyrophenones. In mice, the b-wave exhibited a significant decrease in amplitude if more than 20 mg/kg haloperidol was injected [18]. In their preliminary experiments, there were no significant changes in the ERG when injecting 2.5 or 5.0 mg/kg haloperidol.…”

Section: Discussionmentioning

confidence: 93%

Standardized full-field electroretinography in rabbits

2004

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We present a procedure for full-field ERG recording in rabbits, based on the human ERG standards published by the International Society for Clinical Electrophysiology of Vision (ISCEV). Following initial pilot experiments, six animals aged 3 months and 11 animals between 1 and 2 years were investigated. All animals displayed well detectable and reproducible separate cone and rod responses under appropriate stimulus conditions. The b-wave was smaller in young animals than in old, but there were no similar differences in the b-wave implicit times. The animals had to be lightly sedated, which was shown to have no adverse effects on the recordings. Standard deviations of normalized adult rabbit recordings were comparable to human recordings. The measurements were less precise in young animals. We suggest that our procedure is well suited for further scientific studies in this animal model.

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Section: Discussionmentioning

confidence: 93%

Standardized full-field electroretinography in rabbits

2004

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Role of dopamine in distal retina

Popova

2014

J Comp Physiol A

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Dopamine is the most abundant catecholamine in the vertebrate retina. Despite the description of retinal dopaminergic cells three decades ago, many aspects of their function in the retina remain unclear. There is no consensus among the authors about the stimulus conditions for dopamine release (darkness, steady or flickering light) as well as about its action upon the various types of retinal cells. Many contradictory results exist concerning the dopamine effect on the gross electrical activity of the retina [reflected in electroretinogram (ERG)] and the receptors involved in its action. This review summarized current knowledge about the types of the dopaminergic neurons and receptors in the retina as well as the effects of dopamine receptor agonists and antagonists on the light responses of photoreceptors, horizontal and bipolar cells in both nonmammalian and mammalian retina. Special focus of interest concerns their effects upon the diffuse ERG as a useful tool for assessment of the overall function of the distal retina. An attempt is made to reveal some differences between the dopamine actions upon the activity of the ON versus OFF channel in the distal retina. The author has included her own results demonstrating such differences.

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